GO Annotations Graph

• Symbol: Grb2
• Name: growth factor receptor bound protein 2
• ID: MGI:95805

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:177164
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:164563
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0005154	epidermal growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0005091	guanyl-nucleotide exchange factor adaptor activity	IDA	J:326666
Molecular Function	GO:0005091	guanyl-nucleotide exchange factor adaptor activity	IDA	J:326666
Molecular Function	GO:0005091	guanyl-nucleotide exchange factor adaptor activity	IDA	J:326914
Molecular Function	GO:0005091	guanyl-nucleotide exchange factor adaptor activity	ISO	J:327224
Molecular Function	GO:0005091	guanyl-nucleotide exchange factor adaptor activity	IDA	J:327412
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0043560	insulin receptor substrate binding	ISO	J:164563
Molecular Function	GO:0043560	insulin receptor substrate binding	ISO	J:155856
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:326666
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:326666
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:326914
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:327224
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:327412
Molecular Function	GO:0005168	neurotrophin TRKA receptor binding	ISO	J:164563
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:155856
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:155856
Molecular Function	GO:0001784	phosphotyrosine residue binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:178776
Molecular Function	GO:0005515	protein binding	IPI	J:190009
Molecular Function	GO:0005515	protein binding	IPI	J:276512
Molecular Function	GO:0005515	protein binding	IPI	J:277874
Molecular Function	GO:0005515	protein binding	IPI	J:151076
Molecular Function	GO:0005515	protein binding	IPI	J:172064
Molecular Function	GO:0005515	protein binding	IPI	J:244275
Molecular Function	GO:0005515	protein binding	IPI	J:151075
Molecular Function	GO:0005515	protein binding	IPI	J:72778
Molecular Function	GO:0005515	protein binding	IPI	J:116377
Molecular Function	GO:0005515	protein binding	IPI	J:113920
Molecular Function	GO:0005515	protein binding	IPI	J:200332
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:154859
Molecular Function	GO:0005515	protein binding	IPI	J:76319
Molecular Function	GO:0005515	protein binding	IPI	J:159072
Molecular Function	GO:0005515	protein binding	IPI	J:133325
Molecular Function	GO:0005515	protein binding	IPI	J:200336
Molecular Function	GO:0005515	protein binding	IPI	J:200516
Molecular Function	GO:0005515	protein binding	IPI	J:186446
Molecular Function	GO:0005515	protein binding	IPI	J:128861
Molecular Function	GO:0005515	protein binding	IPI	J:200364
Molecular Function	GO:0005515	protein binding	IPI	J:213907
Molecular Function	GO:0005515	protein binding	IPI	J:201317
Molecular Function	GO:0005515	protein binding	IPI	J:200362
Molecular Function	GO:0005515	protein binding	IPI	J:200360
Molecular Function	GO:0005515	protein binding	IPI	J:200359
Molecular Function	GO:0005515	protein binding	IPI	J:188792
Molecular Function	GO:0005515	protein binding	IPI	J:232061
Molecular Function	GO:0005515	protein binding	IPI	J:209882
Molecular Function	GO:0005515	protein binding	IPI	J:200409
Molecular Function	GO:0005515	protein binding	IPI	J:53497
Molecular Function	GO:0005515	protein binding	IPI	J:206901
Molecular Function	GO:0005515	protein binding	IPI	J:153235
Molecular Function	GO:0005515	protein binding	IPI	J:114724
Molecular Function	GO:0005515	protein binding	IPI	J:72874
Molecular Function	GO:0005515	protein binding	IPI	J:78670
Molecular Function	GO:0005515	protein binding	IPI	J:76181
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:73962
Molecular Function	GO:0005515	protein binding	IPI	J:129312
Molecular Function	GO:0005515	protein binding	IPI	J:31423
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0005515	protein binding	IPI	J:55014
Molecular Function	GO:0005515	protein binding	IPI	J:76181
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0005515	protein binding	IPI	J:189787
Molecular Function	GO:0005515	protein binding	IPI	J:68972
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:104992
Molecular Function	GO:0005515	protein binding	IPI	J:94716
Molecular Function	GO:0005515	protein binding	IPI	J:73116
Molecular Function	GO:0005515	protein binding	IPI	J:40779
Molecular Function	GO:0005515	protein binding	IPI	J:94527
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:57558
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	IPI	J:169648
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IDA	J:14183
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IGI	J:125303
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0008180	COP9 signalosome	ISO	J:164563
Cellular Component	GO:0008180	COP9 signalosome	IDA	J:186446
Cellular Component	GO:0008180	COP9 signalosome	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:98531
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730846
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730869
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983356
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9007126
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9007137
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029146
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029152
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029162
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-914067
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9604768
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9606621
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9606623
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9606789
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9607226
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9645128
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9645133
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9645136
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674973
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682572
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9763903
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9764150
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9036961
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0070436	Grb2-EGFR complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:99862
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:128987
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0012506	vesicle membrane	IDA	J:79320
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	IMP	J:69138
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:326666
Biological Process	GO:0060670	branching involved in labyrinthine layer morphogenesis	IMP	J:69138
Biological Process	GO:0071479	cellular response to ionizing radiation	ISO	J:164563
Biological Process	GO:0035987	endodermal cell differentiation	IMP	J:114676
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:125303
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:73116
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:73116
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:73116
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:327224
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:110842
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:81182
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:307414
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IGI	J:128987
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0007265	Ras protein signal transduction	TAS	J:23345
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0043408	regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0043408	regulation of MAPK cascade	IGI	J:94527
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0042770	signal transduction in response to DNA damage	ISO	J:164563