GO Annotations Graph

• Symbol: Gnas
• Name: GNAS complex locus
• ID: MGI:95777

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0010856	adenylate cyclase activator activity	ISO	J:155856
Molecular Function	GO:0010856	adenylate cyclase activator activity	IDA	J:131258
Molecular Function	GO:0010856	adenylate cyclase activator activity	IDA	J:131258
Molecular Function	GO:0010856	adenylate cyclase activator activity	IMP	J:331361
Molecular Function	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity	ISO	J:180724
Molecular Function	GO:0043014	alpha-tubulin binding	ISO	J:155856
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	IBA	J:265628
Molecular Function	GO:0051430	corticotropin-releasing hormone receptor 1 binding	ISO	J:155856
Molecular Function	GO:0051430	corticotropin-releasing hormone receptor 1 binding	IBA	J:265628
Molecular Function	GO:0031748	D1 dopamine receptor binding	ISO	J:155856
Molecular Function	GO:0031748	D1 dopamine receptor binding	IBA	J:265628
Molecular Function	GO:0003925	G protein activity	IMP	J:331361
Molecular Function	GO:0001965	G-protein alpha-subunit binding	ISO	J:155856
Molecular Function	GO:0031681	G-protein beta-subunit binding	ISO	J:155856
Molecular Function	GO:0031683	G-protein beta/gamma-subunit complex binding	IBA	J:265628
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0003924	GTPase activity	TAS	J:10067
Molecular Function	GO:0003924	GTPase activity	ISO	J:8410
Molecular Function	GO:0019001	guanyl nucleotide binding	IEA	J:72247
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0031852	mu-type opioid receptor binding	ISO	J:155856
Molecular Function	GO:0031852	mu-type opioid receptor binding	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:240496
Molecular Function	GO:0005515	protein binding	IPI	J:202979
Molecular Function	GO:0005515	protein binding	IPI	J:38464
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0030142	COPI-coated Golgi to ER transport vesicle	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IDA	J:156502
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0005834	heterotrimeric G-protein complex	ISO	J:155856
Cellular Component	GO:0005834	heterotrimeric G-protein complex	IBA	J:265628
Cellular Component	GO:0005834	heterotrimeric G-protein complex	TAS	J:10067
Cellular Component	GO:0005834	heterotrimeric G-protein complex	ISO	J:8410
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IMP	J:43721
Cellular Component	GO:0016020	membrane	IDA	J:38464
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:131258
Cellular Component	GO:0005886	plasma membrane	IDA	J:131258
Cellular Component	GO:0055037	recycling endosome	ISO	J:155856
Cellular Component	GO:0001726	ruffle	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0032588	trans-Golgi network membrane	ISO	J:164563
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IGI	J:119081
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IGI	J:119081
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:131258
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	J:311843
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:309740
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:8410
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:45409
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:43721
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:31020
Biological Process	GO:0060348	bone development	ISO	J:164563
Biological Process	GO:0060348	bone development	ISO	J:164563
Biological Process	GO:0060348	bone development	ISO	J:164563
Biological Process	GO:0055074	calcium ion homeostasis	ISO	J:155856
Biological Process	GO:0051216	cartilage development	IMP	J:106979
Biological Process	GO:0071870	cellular response to catecholamine stimulus	ISO	J:155856
Biological Process	GO:0071377	cellular response to glucagon stimulus	IMP	J:102504
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	ISO	J:155856
Biological Process	GO:0050890	cognition	ISO	J:164563
Biological Process	GO:0050890	cognition	ISO	J:164563
Biological Process	GO:0048589	developmental growth	ISO	J:164563
Biological Process	GO:0048589	developmental growth	ISO	J:164563
Biological Process	GO:0048589	developmental growth	ISO	J:164563
Biological Process	GO:0006306	DNA methylation	IMP	J:160293
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:106979
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IMP	J:106979
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IMP	J:106979
Biological Process	GO:0001958	endochondral ossification	IMP	J:106979
Biological Process	GO:0006112	energy reserve metabolic process	IMP	J:60971
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	TAS	J:10067
Biological Process	GO:0071514	genomic imprinting	IMP	J:160293
Biological Process	GO:0060789	hair follicle placode formation	ISO	J:164563
Biological Process	GO:0060789	hair follicle placode formation	ISO	J:164563
Biological Process	GO:0035264	multicellular organism growth	IMP	J:160293
Biological Process	GO:0045776	negative regulation of blood pressure	ISO	J:155856
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IMP	J:201517
Biological Process	GO:0035814	negative regulation of renal sodium excretion	ISO	J:155856
Biological Process	GO:0070527	platelet aggregation	ISO	J:164563
Biological Process	GO:0070527	platelet aggregation	ISO	J:164563
Biological Process	GO:0070527	platelet aggregation	ISO	J:164563
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:159612
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	IDA	J:131258
Biological Process	GO:0032024	positive regulation of insulin secretion	IGI	J:311843
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:309740
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:106979
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IMP	J:106979
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0010765	positive regulation of sodium ion transport	ISO	J:155856
Biological Process	GO:0040032	post-embryonic body morphogenesis	IMP	J:106979
Biological Process	GO:0009791	post-embryonic development	IMP	J:160293
Biological Process	GO:0009791	post-embryonic development	IMP	J:106979
Biological Process	GO:2000828	regulation of parathyroid hormone secretion	IMP	J:97229
Biological Process	GO:0009966	regulation of signal transduction	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0071107	response to parathyroid hormone	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:70175
Biological Process	GO:0007606	sensory perception of chemical stimulus	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0001501	skeletal system development	IMP	J:106979
Biological Process	GO:0043588	skin development	IMP	J:160293
Biological Process	GO:0001894	tissue homeostasis	IMP	J:160293