GO Annotations Graph

• Symbol: Ptk2
• Name: PTK2 protein tyrosine kinase 2
• ID: MGI:95481

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0008432	JUN kinase binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IMP	J:231279
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IMP	J:240718
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019902	phosphatase binding	ISO	J:155856
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:200373
Molecular Function	GO:0005515	protein binding	IPI	J:269564
Molecular Function	GO:0005515	protein binding	IPI	J:322372
Molecular Function	GO:0005515	protein binding	IPI	J:136695
Molecular Function	GO:0005515	protein binding	IPI	J:273522
Molecular Function	GO:0005515	protein binding	IPI	J:36262
Molecular Function	GO:0005515	protein binding	IPI	J:138258
Molecular Function	GO:0005515	protein binding	IPI	J:200352
Molecular Function	GO:0005515	protein binding	IPI	J:116386
Molecular Function	GO:0005515	protein binding	IPI	J:116386
Molecular Function	GO:0005515	protein binding	IPI	J:200353
Molecular Function	GO:0005515	protein binding	IPI	J:200355
Molecular Function	GO:0005515	protein binding	IPI	J:45798
Molecular Function	GO:0005515	protein binding	IPI	J:180487
Molecular Function	GO:0005515	protein binding	IPI	J:240718
Molecular Function	GO:0005515	protein binding	IPI	J:217307
Molecular Function	GO:0005515	protein binding	IPI	J:217307
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:180501
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:231277
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:116386
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:322372
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-420394
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-421694
Molecular Function	GO:0004713	protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:61486
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0036064	ciliary basal body	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-3928599
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-3928630
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-420382
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-420394
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-421693
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-421694
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5218834
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5218849
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	IDA	J:231279
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	IDA	J:73970
Cellular Component	GO:0005925	focal adhesion	IDA	J:80946
Cellular Component	GO:0005925	focal adhesion	IDA	J:104986
Cellular Component	GO:0005925	focal adhesion	IDA	J:98248
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231277
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:231277
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:231277
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:231277
Cellular Component	GO:0014704	intercalated disc	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IDA	J:98248
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016604	nuclear body	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:180459
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0001725	stress fiber	ISO	J:164563
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IMP	J:99637
Biological Process	GO:0007409	axonogenesis	IMP	J:93215
Biological Process	GO:0007409	axonogenesis	IMP	J:93215
Biological Process	GO:0001568	blood vessel development	IMP	J:99637
Biological Process	GO:0001568	blood vessel development	IMP	J:82150
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IDA	J:176254
Biological Process	GO:0021955	central nervous system neuron axonogenesis	IMP	J:93215
Biological Process	GO:0021955	central nervous system neuron axonogenesis	IMP	J:93215
Biological Process	GO:0043542	endothelial cell migration	IMP	J:99637
Biological Process	GO:0048013	ephrin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0030198	extracellular matrix organization	IMP	J:86453
Biological Process	GO:0060396	growth hormone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0007229	integrin-mediated signaling pathway	TAS	J:73970
Biological Process	GO:0030644	intracellular chloride ion homeostasis	ISO	J:155856
Biological Process	GO:0007254	JNK cascade	ISO	J:155856
Biological Process	GO:0000165	MAPK cascade	ISO	J:155856
Biological Process	GO:0000226	microtubule cytoskeleton organization	IDA	J:85235
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:2000811	negative regulation of anoikis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010507	negative regulation of autophagy	IDA	J:240718
Biological Process	GO:0010507	negative regulation of autophagy	IMP	J:240718
Biological Process	GO:0050771	negative regulation of axonogenesis	IMP	J:93215
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:155856
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	ISO	J:164563
Biological Process	GO:0046621	negative regulation of organ growth	IGI	J:105371
Biological Process	GO:0051964	negative regulation of synapse assembly	IMP	J:93215
Biological Process	GO:0001764	neuron migration	IMP	J:86453
Biological Process	GO:0001764	neuron migration	IDA	J:85235
Biological Process	GO:0007097	nuclear migration	IDA	J:85235
Biological Process	GO:0035265	organ growth	IGI	J:105371
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	IDA	J:240718
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:180501
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:231279
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:240718
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	IDA	J:240718
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:180459
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:164563
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	ISO	J:164563
Biological Process	GO:0120041	positive regulation of macrophage proliferation	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0050806	positive regulation of synaptic transmission	ISO	J:155856
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	IMP	J:180459
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:180501
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IMP	J:638
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0010632	regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:0051893	regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	IDA	J:231277
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	IMP	J:231277
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	IDA	J:231277
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	IMP	J:231277
Biological Process	GO:0045667	regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0001932	regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:1900024	regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0007172	signal complex assembly	IEA	J:72247
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001570	vasculogenesis	IMP	J:99637
Biological Process	GO:0042311	vasodilation	ISO	J:155856