Ercc2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Ercc2
excision repair cross-complementing rodent repair deficiency, complementation group 2
MGI:95413

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0043139	5'-3' DNA helicase activity	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003684	damaged DNA binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003678	DNA helicase activity	IBA	J:265628
Molecular Function	GO:0004386	helicase activity	IEA	J:72247
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA	J:72247
Molecular Function	GO:0051536	iron-sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Cellular Component	GO:0070516	CAK-ERCC2 complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0071817	MMXD complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:130306
Cellular Component	GO:0005819	spindle	ISO	J:164563
Cellular Component	GO:0005669	transcription factor TFIID complex	ISO	J:164563
Cellular Component	GO:0000439	transcription factor TFIIH core complex	ISO	J:164563
Cellular Component	GO:0000439	transcription factor TFIIH core complex	ISO	J:155856
Cellular Component	GO:0005675	transcription factor TFIIH holo complex	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0030282	bone mineralization	IMP	J:116054
Biological Process	GO:0032289	central nervous system myelin formation	IMP	J:130306
Biological Process	GO:0007059	chromosome segregation	ISO	J:164563
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:116054
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:76608
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IMP	J:76608
Biological Process	GO:0040016	embryonic cleavage	IMP	J:45017
Biological Process	GO:0043249	erythrocyte maturation	IMP	J:116054
Biological Process	GO:0030198	extracellular matrix organization	IMP	J:48256
Biological Process	GO:0035315	hair cell differentiation	ISO	J:164563
Biological Process	GO:0035315	hair cell differentiation	IMP	J:116054
Biological Process	GO:0022405	hair cycle process	IMP	J:116054
Biological Process	GO:0048820	hair follicle maturation	IMP	J:48256
Biological Process	GO:0060218	hematopoietic stem cell differentiation	IMP	J:122781
Biological Process	GO:0071425	hematopoietic stem cell proliferation	IMP	J:122781
Biological Process	GO:0001701	in utero embryonic development	IMP	J:116054
Biological Process	GO:0001701	in utero embryonic development	IMP	J:116054
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:137150
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	IMP	J:137150
Biological Process	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP	J:198536
Biological Process	GO:0035264	multicellular organism growth	IMP	J:116054
Biological Process	GO:0006139	nucleobase-containing compound metabolic process	IEA	J:72247
Biological Process	GO:0006289	nucleotide-excision repair	ISO	J:73065
Biological Process	GO:0006289	nucleotide-excision repair	IMP	J:76608
Biological Process	GO:0006289	nucleotide-excision repair	IMP	J:48256
Biological Process	GO:0043388	positive regulation of DNA binding	IMP	J:130306
Biological Process	GO:0045951	positive regulation of mitotic recombination	IBA	J:265628
Biological Process	GO:0009791	post-embryonic development	IMP	J:116054
Biological Process	GO:0009791	post-embryonic development	IMP	J:76608
Biological Process	GO:1901990	regulation of mitotic cell cycle phase transition	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	IMP	J:76608
Biological Process	GO:0009411	response to UV	IMP	J:116054
Biological Process	GO:0042274	ribosomal small subunit biogenesis	IMP	J:198536
Biological Process	GO:0043588	skin development	IMP	J:116054
Biological Process	GO:0043588	skin development	IMP	J:48256
Biological Process	GO:0043588	skin development	IMP	J:116054
Biological Process	GO:0043588	skin development	IMP	J:48256
Biological Process	GO:0021510	spinal cord development	IMP	J:116054
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006366	transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006362	transcription elongation by RNA polymerase I	IMP	J:198536
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	ISO	J:164563
Biological Process	GO:0009650	UV protection	ISO	J:73065
Biological Process	GO:0009650	UV protection	IMP	J:48256

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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