Edn1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Edn1
endothelin 1
MGI:95283

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0031707	endothelin A receptor binding	ISO	J:164563
Molecular Function	GO:0031707	endothelin A receptor binding	ISO	J:155856
Molecular Function	GO:0031707	endothelin A receptor binding	IBA	J:265628
Molecular Function	GO:0031707	endothelin A receptor binding	IPI	J:46639
Molecular Function	GO:0031708	endothelin B receptor binding	ISO	J:164563
Molecular Function	GO:0031708	endothelin B receptor binding	ISO	J:155856
Molecular Function	GO:0031708	endothelin B receptor binding	IBA	J:265628
Molecular Function	GO:0005179	hormone activity	ISO	J:164563
Molecular Function	GO:0005179	hormone activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:81728
Molecular Function	GO:0005102	signaling receptor binding	IDA	J:22583
Molecular Function	GO:0005102	signaling receptor binding	IDA	J:29595
Cellular Component	GO:0045178	basal part of cell	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:91968
Cellular Component	GO:0048237	rough endoplasmic reticulum lumen	ISO	J:155856
Cellular Component	GO:0033093	Weibel-Palade body	ISO	J:155856
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	J:22583
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IGI	J:104785
Biological Process	GO:0014824	artery smooth muscle contraction	ISO	J:155856
Biological Process	GO:0014824	artery smooth muscle contraction	ISO	J:164563
Biological Process	GO:0048675	axon extension	IDA	J:133765
Biological Process	GO:0060385	axonogenesis involved in innervation	IMP	J:274700
Biological Process	GO:0060385	axonogenesis involved in innervation	IMP	J:250662
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:26778
Biological Process	GO:0007589	body fluid secretion	IMP	J:91968
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:204461
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:26778
Biological Process	GO:0070588	calcium ion transmembrane transport	IDA	J:293877
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0060070	canonical Wnt signaling pathway	IDA	J:293877
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	IDA	J:279375
Biological Process	GO:0051216	cartilage development	IMP	J:17694
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007267	cell-cell signaling	ISO	J:164563
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	IDA	J:145765
Biological Process	GO:0044751	cellular response to human chorionic gonadotropin stimulus	IDA	J:145765
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:290945
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:290945
Biological Process	GO:0071373	cellular response to luteinizing hormone stimulus	IDA	J:145765
Biological Process	GO:0071310	cellular response to organic substance	IMP	J:290945
Biological Process	GO:0071310	cellular response to organic substance	ISO	J:290945
Biological Process	GO:0071310	cellular response to organic substance	IDA	J:290945
Biological Process	GO:0071310	cellular response to organic substance	IMP	J:290945
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:90465
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:90465
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:279375
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:274700
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:274700
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:250662
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:250662
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:279375
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:250662
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:274700
Biological Process	GO:0086100	endothelin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0086101	endothelin receptor signaling pathway involved in heart process	IDA	J:279375
Biological Process	GO:0042045	epithelial fluid transport	ISO	J:155856
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IDA	J:166932
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	TAS	J:72781
Biological Process	GO:0010467	gene expression	IMP	J:196635
Biological Process	GO:0010467	gene expression	IMP	J:274700
Biological Process	GO:0010467	gene expression	IDA	J:293877
Biological Process	GO:0010467	gene expression	IMP	J:274700
Biological Process	GO:0010467	gene expression	IMP	J:274700
Biological Process	GO:0010467	gene expression	IDA	J:166932
Biological Process	GO:0007507	heart development	IMP	J:250662
Biological Process	GO:0007507	heart development	IMP	J:250662
Biological Process	GO:0007507	heart development	IMP	J:26778
Biological Process	GO:0007507	heart development	IMP	J:26778
Biological Process	GO:0001821	histamine secretion	ISO	J:155856
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:293877
Biological Process	GO:0001701	in utero embryonic development	IMP	J:93876
Biological Process	GO:0048016	inositol phosphate-mediated signaling	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IBA	J:265628
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IDA	J:290945
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:290945
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0000165	MAPK cascade	IMP	J:145765
Biological Process	GO:0000165	MAPK cascade	IDA	J:145765
Biological Process	GO:1903537	meiotic cell cycle process involved in oocyte maturation	IDA	J:145765
Biological Process	GO:0051899	membrane depolarization	ISO	J:155856
Biological Process	GO:0042474	middle ear morphogenesis	IMP	J:17694
Biological Process	GO:0007005	mitochondrion organization	IDA	J:246633
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0046888	negative regulation of hormone secretion	ISO	J:155856
Biological Process	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	ISO	J:164563
Biological Process	GO:0051248	negative regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0034392	negative regulation of smooth muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0014032	neural crest cell development	IMP	J:93876
Biological Process	GO:0014032	neural crest cell development	IMP	J:49658
Biological Process	GO:0014032	neural crest cell development	IMP	J:49658
Biological Process	GO:0014032	neural crest cell development	IMP	J:49658
Biological Process	GO:0014032	neural crest cell development	IMP	J:49658
Biological Process	GO:0014033	neural crest cell differentiation	IMP	J:204461
Biological Process	GO:0014034	neural crest cell fate commitment	IMP	J:204461
Biological Process	GO:0031175	neuron projection development	IDA	J:250662
Biological Process	GO:0030185	nitric oxide transport	ISO	J:164563
Biological Process	GO:0003357	noradrenergic neuron differentiation	IMP	J:250662
Biological Process	GO:0003357	noradrenergic neuron differentiation	IMP	J:250662
Biological Process	GO:0030072	peptide hormone secretion	ISO	J:164563
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	IMP	J:204461
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	IMP	J:204461
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	IMP	J:204461
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0031583	phospholipase D-activating G protein-coupled receptor signaling pathway	IDA	J:37347
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:164563
Biological Process	GO:2001259	positive regulation of cation channel activity	ISO	J:290945
Biological Process	GO:2001259	positive regulation of cation channel activity	ISO	J:290945
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:22583
Biological Process	GO:0045793	positive regulation of cell size	ISO	J:164563
Biological Process	GO:0070101	positive regulation of chemokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IDA	J:22583
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:164563
Biological Process	GO:0046887	positive regulation of hormone secretion	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	ISO	J:155856
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0042482	positive regulation of odontogenesis	ISO	J:155856
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	ISO	J:155856
Biological Process	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	ISO	J:164563
Biological Process	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	IBA	J:265628
Biological Process	GO:0035815	positive regulation of renal sodium excretion	IMP	J:91968
Biological Process	GO:0060298	positive regulation of sarcomere organization	ISO	J:164563
Biological Process	GO:2000273	positive regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	IDA	J:28504
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0035810	positive regulation of urine volume	IGI	J:104785
Biological Process	GO:0035810	positive regulation of urine volume	IMP	J:104785
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0010737	protein kinase A signaling	ISO	J:290945
Biological Process	GO:0042313	protein kinase C deactivation	ISO	J:164563
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	IDA	J:22583
Biological Process	GO:0006468	protein phosphorylation	IDA	J:279375
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:155856
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:116002
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:196635
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:91968
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:17694
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:60070
Biological Process	GO:0010827	regulation of glucose transmembrane transport	IDA	J:72781
Biological Process	GO:0006885	regulation of pH	IDA	J:70015
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0003100	regulation of systemic arterial blood pressure by endothelin	ISO	J:164563
Biological Process	GO:0003100	regulation of systemic arterial blood pressure by endothelin	IBA	J:265628
Biological Process	GO:0019229	regulation of vasoconstriction	IEA	J:72247
Biological Process	GO:0070294	renal sodium ion absorption	IDA	J:200848
Biological Process	GO:0007585	respiratory gaseous exchange by respiratory system	IMP	J:60070
Biological Process	GO:0001975	response to amphetamine	IMP	J:250662
Biological Process	GO:0001666	response to hypoxia	IMP	J:34053
Biological Process	GO:0001666	response to hypoxia	IMP	MGI:MGI:892631
Biological Process	GO:0043179	rhythmic excitation	IMP	J:34053
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IMP	J:274700
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IMP	J:274700
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IMP	J:274700
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0001501	skeletal system development	IMP	J:17694
Biological Process	GO:0001501	skeletal system development	IMP	J:17694
Biological Process	GO:0001501	skeletal system development	IMP	J:17694
Biological Process	GO:0006939	smooth muscle contraction	IDA	J:28504
Biological Process	GO:0042554	superoxide anion generation	ISO	J:155856
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0030878	thyroid gland development	IMP	J:228793
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:293570
Biological Process	GO:0042310	vasoconstriction	ISO	J:155856
Biological Process	GO:0042310	vasoconstriction	ISO	J:164563
Biological Process	GO:0014826	vein smooth muscle contraction	ISO	J:164563
Biological Process	GO:0014826	vein smooth muscle contraction	IBA	J:265628

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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