GO Annotations Graph

• Symbol: Drd2
• Name: dopamine receptor D2
• ID: MGI:94924

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0035240	dopamine binding	ISO	J:155856
Molecular Function	GO:0035240	dopamine binding	IDA	J:96985
Molecular Function	GO:0004952	dopamine neurotransmitter receptor activity	IDA	J:140050
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISO	J:164563
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISO	J:155856
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISO	J:164563
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IBA	J:265628
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	J:65767
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:86377
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	J:97838
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	J:67550
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:29045
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:29045
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:112986
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	J:98436
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	J:97838
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	J:65767
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:16494
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	J:65767
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:34152
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	J:97838
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	J:41857
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:10932
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:65023
Molecular Function	GO:0004930	G protein-coupled receptor activity	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IDA	J:88364
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0097159	organic cyclic compound binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:224553
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Cellular Component	GO:0001669	acrosomal vesicle	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IDA	J:52509
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0060170	ciliary membrane	ISO	J:164563
Cellular Component	GO:0005929	cilium	ISO	J:246963
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:52509
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:79144
Cellular Component	GO:0098691	dopaminergic synapse	EXP	J:79144
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:79144
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:79144
Cellular Component	GO:0098691	dopaminergic synapse	EXP	J:79144
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:79144
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:232120
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:232120
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:232120
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:232120
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0016328	lateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0097730	non-motile cilium	ISO	J:164563
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:232120
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:232120
Cellular Component	GO:0098793	presynapse	EXP	J:79144
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:232120
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:232120
Cellular Component	GO:0036126	sperm flagellum	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Biological Process	GO:0046717	acid secretion	ISO	J:155856
Biological Process	GO:0032147	activation of protein kinase activity	ISO	J:155856
Biological Process	GO:0021984	adenohypophysis development	IMP	J:97838
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA	J:83301
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IGI	J:79146
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IGI	J:79146
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0030534	adult behavior	IMP	J:103562
Biological Process	GO:0007628	adult walking behavior	IMP	J:29045
Biological Process	GO:0050482	arachidonic acid secretion	ISO	J:164563
Biological Process	GO:0008306	associative learning	IMP	J:97757
Biological Process	GO:0008306	associative learning	IMP	J:90593
Biological Process	GO:0008306	associative learning	IMP	J:77342
Biological Process	GO:0031223	auditory behavior	ISO	J:155856
Biological Process	GO:0006914	autophagy	ISO	J:155856
Biological Process	GO:0007409	axonogenesis	IMP	J:70177
Biological Process	GO:0048148	behavioral response to cocaine	IMP	J:120951
Biological Process	GO:0048149	behavioral response to ethanol	IMP	J:103087
Biological Process	GO:0048149	behavioral response to ethanol	IMP	J:103899
Biological Process	GO:0048149	behavioral response to ethanol	IMP	J:102654
Biological Process	GO:0048755	branching morphogenesis of a nerve	IMP	J:70177
Biological Process	GO:0016477	cell migration	IMP	J:121219
Biological Process	GO:0008283	cell population proliferation	IMP	J:41858
Biological Process	GO:0008283	cell population proliferation	IMP	J:97838
Biological Process	GO:0008283	cell population proliferation	IMP	J:41857
Biological Process	GO:0008283	cell population proliferation	IMP	J:97838
Biological Process	GO:0008283	cell population proliferation	IMP	J:58342
Biological Process	GO:0008283	cell population proliferation	IGI	J:41857
Biological Process	GO:0008283	cell population proliferation	IMP	J:58342
Biological Process	GO:0008283	cell population proliferation	IMP	J:110599
Biological Process	GO:0008283	cell population proliferation	IMP	J:41858
Biological Process	GO:0008283	cell population proliferation	IMP	J:41857
Biological Process	GO:0008283	cell population proliferation	IMP	J:110599
Biological Process	GO:0008283	cell population proliferation	IGI	J:41857
Biological Process	GO:0021853	cerebral cortex GABAergic interneuron migration	IMP	J:121219
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:109095
Biological Process	GO:0042417	dopamine metabolic process	IMP	J:20835
Biological Process	GO:0007212	dopamine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007212	dopamine receptor signaling pathway	IGI	J:109223
Biological Process	GO:0007212	dopamine receptor signaling pathway	IGI	J:109223
Biological Process	GO:0051583	dopamine uptake involved in synaptic transmission	IMP	J:52172
Biological Process	GO:0042756	drinking behavior	ISO	J:155856
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:41857
Biological Process	GO:0050673	epithelial cell proliferation	IGI	J:41857
Biological Process	GO:0007631	feeding behavior	IGI	J:91781
Biological Process	GO:0030900	forebrain development	ISO	J:155856
Biological Process	GO:0002031	G protein-coupled receptor internalization	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IDA	J:88364
Biological Process	GO:0007625	grooming behavior	IMP	J:61315
Biological Process	GO:1990384	hyaloid vascular plexus regression	IMP	J:279052
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0007626	locomotory behavior	ISO	J:155856
Biological Process	GO:0007626	locomotory behavior	IGI	J:102700
Biological Process	GO:0007626	locomotory behavior	IMP	J:106290
Biological Process	GO:0007626	locomotory behavior	IGI	J:91781
Biological Process	GO:0007626	locomotory behavior	IGI	J:96229
Biological Process	GO:0007626	locomotory behavior	IGI	J:43791
Biological Process	GO:0007626	locomotory behavior	IGI	J:102700
Biological Process	GO:0007626	locomotory behavior	IMP	J:47001
Biological Process	GO:0007626	locomotory behavior	IMP	J:77342
Biological Process	GO:0007626	locomotory behavior	IMP	J:103087
Biological Process	GO:0007626	locomotory behavior	IMP	J:100036
Biological Process	GO:0007626	locomotory behavior	IGI	J:43791
Biological Process	GO:0007626	locomotory behavior	IGI	J:66955
Biological Process	GO:0007626	locomotory behavior	IGI	J:63612
Biological Process	GO:0007626	locomotory behavior	IMP	J:59505
Biological Process	GO:0007626	locomotory behavior	IMP	J:103795
Biological Process	GO:0007626	locomotory behavior	IGI	J:67550
Biological Process	GO:0007626	locomotory behavior	IMP	J:61315
Biological Process	GO:0007626	locomotory behavior	IMP	J:102654
Biological Process	GO:0007626	locomotory behavior	IMP	J:91838
Biological Process	GO:0007616	long-term memory	ISO	J:155856
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:119592
Biological Process	GO:0007194	negative regulation of adenylate cyclase activity	ISO	J:164563
Biological Process	GO:0045776	negative regulation of blood pressure	IMP	J:103181
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:58342
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:97838
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:41858
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:41857
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:41857
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:110599
Biological Process	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	ISO	J:155856
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	IBA	J:265628
Biological Process	GO:0060160	negative regulation of dopamine receptor signaling pathway	IGI	J:109223
Biological Process	GO:0060160	negative regulation of dopamine receptor signaling pathway	IGI	J:109223
Biological Process	GO:0033602	negative regulation of dopamine secretion	ISO	J:155856
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IGI	J:41857
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:41857
Biological Process	GO:0045824	negative regulation of innate immune response	IMP	J:194407
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:155856
Biological Process	GO:2001223	negative regulation of neuron migration	IMP	J:121219
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:117785
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:117785
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0050709	negative regulation of protein secretion	ISO	J:164563
Biological Process	GO:0050805	negative regulation of synaptic transmission	ISO	J:155856
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	IBA	J:265628
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	IMP	J:103965
Biological Process	GO:1901386	negative regulation of voltage-gated calcium channel activity	ISO	J:164563
Biological Process	GO:1901386	negative regulation of voltage-gated calcium channel activity	ISO	J:155856
Biological Process	GO:0001976	nervous system process involved in regulation of systemic arterial blood pressure	IMP	J:103181
Biological Process	GO:0007405	neuroblast proliferation	IDA	J:121538
Biological Process	GO:0007405	neuroblast proliferation	IDA	J:121538
Biological Process	GO:0007405	neuroblast proliferation	IDA	J:121538
Biological Process	GO:0001764	neuron migration	IMP	J:121219
Biological Process	GO:0007270	neuron-neuron synaptic transmission	IMP	J:77342
Biological Process	GO:0030432	peristalsis	IMP	J:106280
Biological Process	GO:0030432	peristalsis	IGI	J:91781
Biological Process	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	ISO	J:73065
Biological Process	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	IGI	J:119081
Biological Process	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	IGI	J:119081
Biological Process	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	IDA	J:107534
Biological Process	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	IGI	J:119081
Biological Process	GO:0043473	pigmentation	IMP	J:97838
Biological Process	GO:0032467	positive regulation of cytokinesis	ISO	J:164563
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	ISO	J:164563
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IBA	J:265628
Biological Process	GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	IMP	J:52172
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:1900168	positive regulation of glial cell-derived neurotrophic factor production	ISO	J:164563
Biological Process	GO:0060124	positive regulation of growth hormone secretion	IMP	J:106832
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:106832
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IDA	J:121538
Biological Process	GO:0050769	positive regulation of neurogenesis	ISO	J:155856
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:155856
Biological Process	GO:0035815	positive regulation of renal sodium excretion	IMP	J:103181
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0035810	positive regulation of urine volume	IMP	J:103181
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0060134	prepulse inhibition	IMP	J:125166
Biological Process	GO:0060134	prepulse inhibition	IMP	J:55027
Biological Process	GO:0060134	prepulse inhibition	IMP	J:111572
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:200058
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	EXP	J:200058
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:200058
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	EXP	J:79144
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IMP	J:79144
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:79144
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:117785
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:117785
Biological Process	GO:0008104	protein localization	IMP	J:110781
Biological Process	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	IMP	J:79144
Biological Process	GO:0002027	regulation of heart rate	IMP	J:103181
Biological Process	GO:0090325	regulation of locomotion involved in locomotory behavior	ISO	J:155856
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:40956
Biological Process	GO:0043408	regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0051580	regulation of neurotransmitter uptake	IMP	J:79144
Biological Process	GO:0051580	regulation of neurotransmitter uptake	EXP	J:79144
Biological Process	GO:0051580	regulation of neurotransmitter uptake	IDA	J:79144
Biological Process	GO:0043666	regulation of phosphoprotein phosphatase activity	ISO	J:155856
Biological Process	GO:0043266	regulation of potassium ion transport	ISO	J:155856
Biological Process	GO:0043266	regulation of potassium ion transport	IMP	J:103181
Biological Process	GO:0002028	regulation of sodium ion transport	IMP	J:103181
Biological Process	GO:0051823	regulation of synapse structural plasticity	ISO	J:155856
Biological Process	GO:0032228	regulation of synaptic transmission, GABAergic	IMP	J:91838
Biological Process	GO:0032228	regulation of synaptic transmission, GABAergic	IGI	J:112280
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:155856
Biological Process	GO:0001975	response to amphetamine	IMP	J:137069
Biological Process	GO:0001975	response to amphetamine	IGI	J:109223
Biological Process	GO:0001975	response to amphetamine	IGI	J:109223
Biological Process	GO:0042220	response to cocaine	IDA	J:140050
Biological Process	GO:0042220	response to cocaine	IMP	J:76003
Biological Process	GO:0042220	response to cocaine	IMP	J:103795
Biological Process	GO:0034776	response to histamine	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0009416	response to light stimulus	IMP	J:110260
Biological Process	GO:0043278	response to morphine	IMP	J:71890
Biological Process	GO:0043278	response to morphine	IMP	J:111282
Biological Process	GO:0043278	response to morphine	IMP	J:97757
Biological Process	GO:0043278	response to morphine	IMP	J:75904
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	IDA	J:30219
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:114311
Biological Process	GO:0007608	sensory perception of smell	IMP	J:110704
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0001964	startle response	IMP	J:125166
Biological Process	GO:0001659	temperature homeostasis	IMP	J:59505
Biological Process	GO:0001659	temperature homeostasis	IMP	J:137069
Biological Process	GO:0008542	visual learning	IMP	J:109223
Biological Process	GO:0016055	Wnt signaling pathway	ISO	J:155856