GO Annotations Graph

• Symbol: Cdk4
• Name: cyclin dependent kinase 4
• ID: MGI:88357

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	ISO	J:155856
Molecular Function	GO:0030332	cyclin binding	IBA	J:265628
Molecular Function	GO:0030332	cyclin binding	IPI	J:190888
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IDA	J:85481
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IDA	J:85809
Molecular Function	GO:0016301	kinase activity	IDA	J:78410
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:105045
Molecular Function	GO:0005515	protein binding	IPI	J:201309
Molecular Function	GO:0005515	protein binding	IPI	J:201309
Molecular Function	GO:0005515	protein binding	IPI	J:105043
Molecular Function	GO:0005515	protein binding	IPI	J:165553
Molecular Function	GO:0005515	protein binding	IPI	J:118785
Molecular Function	GO:0005515	protein binding	IPI	J:125912
Molecular Function	GO:0005515	protein binding	IPI	J:105045
Molecular Function	GO:0005515	protein binding	IPI	J:119990
Molecular Function	GO:0005515	protein binding	IPI	J:127604
Molecular Function	GO:0005515	protein binding	IPI	J:111799
Molecular Function	GO:0005515	protein binding	IPI	J:219103
Molecular Function	GO:0005515	protein binding	IPI	J:162977
Molecular Function	GO:0005515	protein binding	IPI	J:182377
Molecular Function	GO:0005515	protein binding	IPI	J:158603
Molecular Function	GO:0005515	protein binding	IPI	J:147145
Molecular Function	GO:0005515	protein binding	IPI	J:77997
Molecular Function	GO:0005515	protein binding	IPI	J:82317
Molecular Function	GO:0005515	protein binding	IPI	J:230033
Molecular Function	GO:0005515	protein binding	IPI	J:171849
Molecular Function	GO:0005515	protein binding	IPI	J:19218
Molecular Function	GO:0005515	protein binding	IPI	J:78410
Molecular Function	GO:0005515	protein binding	IPI	J:85809
Molecular Function	GO:0004672	protein kinase activity	IDA	J:82317
Molecular Function	GO:0004672	protein kinase activity	IDA	J:77997
Molecular Function	GO:0004672	protein kinase activity	IDA	J:174697
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:230033
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:182969
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0097128	cyclin D1-CDK4 complex	ISO	J:164563
Cellular Component	GO:0097128	cyclin D1-CDK4 complex	IPI	J:127604
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	ISO	J:164563
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	IDA	J:30542
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	IDA	J:24521
Cellular Component	GO:0097130	cyclin D3-CDK4 complex	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IBA	J:265628
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:230033
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-182564
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912421
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912431
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912462
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912487
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:230033
Cellular Component	GO:0005634	nucleus	IDA	J:95925
Cellular Component	GO:0005634	nucleus	IDA	J:85130
Cellular Component	GO:0005634	nucleus	IDA	J:37447
Cellular Component	GO:0005634	nucleus	IDA	J:95925
Cellular Component	GO:0005634	nucleus	ISO	J:101015
Cellular Component	GO:0005634	nucleus	IDA	J:53930
Cellular Component	GO:0005634	nucleus	IDA	J:95925
Cellular Component	GO:0005634	nucleus	IDA	J:182969
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:230033
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:53930
Biological Process	GO:0060612	adipose tissue development	IMP	J:230033
Biological Process	GO:0060612	adipose tissue development	IMP	J:230033
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0032869	cellular response to insulin stimulus	IMP	J:230033
Biological Process	GO:0071353	cellular response to interleukin-4	IDA	J:30542
Biological Process	GO:1904637	cellular response to ionomycin	IDA	J:30542
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:30542
Biological Process	GO:1904628	cellular response to phorbol 13-acetate 12-myristate	IDA	J:30542
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	NAS	J:320000
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045793	positive regulation of cell size	ISO	J:155856
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:82317
Biological Process	GO:0006468	protein phosphorylation	IDA	J:78410
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:82317
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IBA	J:265628
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	IMP	J:230033
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	IMP	J:230033
Biological Process	GO:0046890	regulation of lipid biosynthetic process	IMP	J:230033
Biological Process	GO:0046890	regulation of lipid biosynthetic process	IMP	J:230033
Biological Process	GO:0050994	regulation of lipid catabolic process	IMP	J:230033
Biological Process	GO:0050994	regulation of lipid catabolic process	IMP	J:230033
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:230033
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:230033
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	IMP	J:85130
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	IMP	J:85130
Biological Process	GO:0010288	response to lead ion	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	IBA	J:265628
Biological Process	GO:0033574	response to testosterone	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IDA	J:77997