GO Annotations Graph

• Symbol: Capn2
• Name: calpain 2
• ID: MGI:88264

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	ISO	J:155856
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	ISO	J:155856
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IDA	J:186714
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	TAS	J:74966
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	ISO	J:125385
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IDA	J:204792
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IDA	J:177589
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0110158	calpain complex	ISO	J:164563
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0000785	chromatin	IDA	J:133944
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:133944
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:204792
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IDA	J:204792
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:133944
Cellular Component	GO:0097038	perinuclear endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-8863416
Cellular Component	GO:0031143	pseudopodium	ISO	J:164563
Biological Process	GO:0048266	behavioral response to pain	ISO	J:155856
Biological Process	GO:0001824	blastocyst development	IMP	J:107240
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:186714
Biological Process	GO:0071230	cellular response to amino acid stimulus	ISO	J:155856
Biological Process	GO:0007520	myoblast fusion	IMP	J:106306
Biological Process	GO:0007520	myoblast fusion	IMP	J:105090
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:1901741	positive regulation of myoblast fusion	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:2001247	positive regulation of phosphatidylcholine biosynthetic process	ISO	J:155856
Biological Process	GO:0016540	protein autoprocessing	ISO	J:155856
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0006508	proteolysis	IDA	J:186714
Biological Process	GO:0006508	proteolysis	NAS	J:320059
Biological Process	GO:0006508	proteolysis	ISO	J:155856
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:0051493	regulation of cytoskeleton organization	IEA	J:72247
Biological Process	GO:0032675	regulation of interleukin-6 production	ISO	J:155856