GO Annotations Graph

• Symbol: Calr
• Name: calreticulin
• ID: MGI:88252

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	IDA	J:175372
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	IDA	J:49094
Molecular Function	GO:0030246	carbohydrate binding	IDA	J:182475
Molecular Function	GO:0042562	hormone binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005506	iron ion binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003729	mRNA binding	ISO	J:164563
Molecular Function	GO:0003729	mRNA binding	IDA	J:140380
Molecular Function	GO:0003729	mRNA binding	ISO	J:155856
Molecular Function	GO:0050681	nuclear androgen receptor binding	ISO	J:164563
Molecular Function	GO:0042277	peptide binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:206895
Molecular Function	GO:0005515	protein binding	IPI	J:215960
Molecular Function	GO:0005515	protein binding	IPI	J:143818
Molecular Function	GO:0005515	protein binding	IPI	J:206895
Molecular Function	GO:0005515	protein binding	IPI	J:206895
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0051082	unfolded protein binding	IEA	J:72247
Cellular Component	GO:0001669	acrosomal vesicle	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISS	J:137567
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:85958
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:242513
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:129009
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:236095
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:198051
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:268046
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:99569
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:188765
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:83403
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:91615
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:73065
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:176439
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:204025
Cellular Component	GO:0005788	endoplasmic reticulum lumen	ISO	J:164563
Cellular Component	GO:0005788	endoplasmic reticulum lumen	IDA	J:169417
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment	IDA	J:257375
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:92195
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2173779
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-3221864
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:92195
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:187529
Cellular Component	GO:0042824	MHC class I peptide loading complex	IMP	J:140383
Cellular Component	GO:0042824	MHC class I peptide loading complex	ISO	J:164563
Cellular Component	GO:0005635	nuclear envelope	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0045335	phagocytic vesicle	TAS	Reactome:R-NUL-1236962
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005844	polysome	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005790	smooth endoplasmic reticulum	ISO	J:155856
Biological Process	GO:0090398	cellular senescence	IMP	J:140380
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0030866	cortical actin cytoskeleton organization	IDA	J:92195
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:164563
Biological Process	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0017148	negative regulation of translation	ISO	J:164563
Biological Process	GO:1901164	negative regulation of trophoblast cell migration	ISO	J:164563
Biological Process	GO:0002502	peptide antigen assembly with MHC class I protein complex	IMP	J:140383
Biological Process	GO:0045787	positive regulation of cell cycle	ISO	J:164563
Biological Process	GO:0045787	positive regulation of cell cycle	IMP	J:140380
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:2000510	positive regulation of dendritic cell chemotaxis	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:175184
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IMP	J:218494
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:140379
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0006611	protein export from nucleus	ISO	J:164563
Biological Process	GO:0006457	protein folding	IBA	J:265628
Biological Process	GO:0034504	protein localization to nucleus	IMP	J:175184
Biological Process	GO:0034504	protein localization to nucleus	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	IDA	J:175372
Biological Process	GO:0040020	regulation of meiotic nuclear division	IDA	J:92195
Biological Process	GO:0061912	selective autophagy	ISO	J:164563
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	IBA	J:265628