B2m GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

B2m
beta-2 microglobulin
MGI:88127

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0023026	MHC class II protein complex binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:139545
Molecular Function	GO:0005515	protein binding	IPI	J:88804
Molecular Function	GO:0005515	protein binding	IPI	J:139545
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:1767
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:1990712	HFE-transferrin receptor complex	ISO	J:164563
Cellular Component	GO:0042824	MHC class I peptide loading complex	ISO	J:164563
Cellular Component	GO:0042612	MHC class I protein complex	IEA	J:60000
Cellular Component	GO:0042612	MHC class I protein complex	IEA	J:72247
Cellular Component	GO:0042613	MHC class II protein complex	IBA	J:265628
Cellular Component	GO:0030670	phagocytic vesicle membrane	TAS	Reactome:R-NUL-1236962
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:0019731	antibacterial humoral response	ISO	J:164563
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	ISO	J:164563
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA	J:265628
Biological Process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	IMP	J:104295
Biological Process	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	IEA	J:60000
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0006968	cellular defense response	TAS	J:65613
Biological Process	GO:0071281	cellular response to iron ion	ISO	J:164563
Biological Process	GO:0071283	cellular response to iron(III) ion	IMP	J:47457
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071316	cellular response to nicotine	ISO	J:164563
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0002381	immunoglobulin production involved in immunoglobulin-mediated immune response	IBA	J:265628
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0006826	iron ion transport	IMP	J:47457
Biological Process	GO:0007611	learning or memory	IMP	J:250585
Biological Process	GO:0007611	learning or memory	IMP	J:228654
Biological Process	GO:0007611	learning or memory	ISO	J:164563
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:67983
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:2000978	negative regulation of forebrain neuron differentiation	ISO	J:164563
Biological Process	GO:2000978	negative regulation of forebrain neuron differentiation	IMP	J:228654
Biological Process	GO:0050768	negative regulation of neurogenesis	IMP	J:228654
Biological Process	GO:0050768	negative regulation of neurogenesis	ISO	J:164563
Biological Process	GO:0010977	negative regulation of neuron projection development	IGI	J:159396
Biological Process	GO:1900121	negative regulation of receptor binding	ISO	J:164563
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	IBA	J:265628
Biological Process	GO:2000774	positive regulation of cellular senescence	ISO	J:164563
Biological Process	GO:1904434	positive regulation of ferrous iron binding	ISO	J:164563
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:1900122	positive regulation of receptor binding	ISO	J:164563
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0050870	positive regulation of T cell activation	IBA	J:265628
Biological Process	GO:0002726	positive regulation of T cell cytokine production	ISO	J:164563
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IMP	J:104295
Biological Process	GO:1904437	positive regulation of transferrin receptor binding	ISO	J:164563
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0042026	protein refolding	IDA	J:139545
Biological Process	GO:0042026	protein refolding	IDA	J:139545
Biological Process	GO:0045646	regulation of erythrocyte differentiation	IMP	J:47457
Biological Process	GO:0034756	regulation of iron ion transport	ISO	J:164563
Biological Process	GO:0003254	regulation of membrane depolarization	ISO	J:164563
Biological Process	GO:0002237	response to molecule of bacterial origin	IMP	J:104295
Biological Process	GO:0007608	sensory perception of smell	IMP	J:63063
Biological Process	GO:0033077	T cell differentiation in thymus	IGI	J:141145
Biological Process	GO:0001913	T cell mediated cytotoxicity	IMP	J:104295

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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