GO Annotations Graph

• Symbol: Atp1a2
• Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
• ID: MGI:88106

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0008556	P-type potassium transmembrane transporter activity	IEA	J:72247
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	ISO	J:155856
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	ISO	J:164563
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	IBA	J:265628
Molecular Function	GO:0030955	potassium ion binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:103813
Molecular Function	GO:0005515	protein binding	IPI	J:103813
Molecular Function	GO:0005515	protein binding	IPI	J:95157
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0031402	sodium ion binding	ISO	J:164563
Molecular Function	GO:0005496	steroid binding	ISO	J:164563
Molecular Function	GO:1990239	steroid hormone binding	ISO	J:155856
Molecular Function	GO:1990239	steroid hormone binding	ISO	J:164563
Molecular Function	GO:0005215	transporter activity	IEA	J:72247
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IDA	J:81899
Cellular Component	GO:0042995	cell projection	IDA	J:83884
Cellular Component	GO:0042995	cell projection	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0014704	intercalated disc	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:81899
Cellular Component	GO:0043025	neuronal cell body	IDA	J:83884
Cellular Component	GO:0031090	organelle membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IDA	J:103813
Cellular Component	GO:0042383	sarcolemma	IDA	J:95157
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	ISO	J:164563
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	ISO	J:155856
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	IBA	J:265628
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	ISO	J:164563
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	IDA	J:103813
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:117414
Biological Process	GO:0021764	amygdala development	IMP	J:83884
Biological Process	GO:0046034	ATP metabolic process	ISO	J:164563
Biological Process	GO:0001662	behavioral fear response	IMP	J:83884
Biological Process	GO:0071260	cellular response to mechanical stimulus	ISO	J:155856
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	IDA	J:102928
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	ISO	J:164563
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	ISO	J:155856
Biological Process	GO:0030007	intracellular potassium ion homeostasis	ISO	J:164563
Biological Process	GO:0030007	intracellular potassium ion homeostasis	IBA	J:265628
Biological Process	GO:0006883	intracellular sodium ion homeostasis	ISO	J:164563
Biological Process	GO:0006883	intracellular sodium ion homeostasis	IBA	J:265628
Biological Process	GO:0040011	locomotion	IMP	J:81899
Biological Process	GO:0035641	locomotory exploration behavior	IMP	J:279940
Biological Process	GO:0098655	monoatomic cation transmembrane transport	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:1903170	negative regulation of calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:1903280	negative regulation of calcium:sodium antiporter activity	ISO	J:155856
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	IMP	J:55191
Biological Process	GO:0045822	negative regulation of heart contraction	IMP	J:55191
Biological Process	GO:0045988	negative regulation of striated muscle contraction	IMP	J:114415
Biological Process	GO:0001504	neurotransmitter uptake	IMP	J:83884
Biological Process	GO:0021989	olfactory cortex development	IMP	J:83884
Biological Process	GO:1990573	potassium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:1990573	potassium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006813	potassium ion transport	ISO	J:155856
Biological Process	GO:1902600	proton transmembrane transport	ISO	J:155856
Biological Process	GO:1902600	proton transmembrane transport	IBA	J:265628
Biological Process	GO:0008217	regulation of blood pressure	IGI	J:102928
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	ISO	J:155856
Biological Process	GO:0006937	regulation of muscle contraction	IMP	J:55191
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	IMP	J:94810
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	IMP	J:81899
Biological Process	GO:0006940	regulation of smooth muscle contraction	IMP	J:95348
Biological Process	GO:0006942	regulation of striated muscle contraction	IMP	J:98210
Biological Process	GO:0002026	regulation of the force of heart contraction	IMP	J:55191
Biological Process	GO:0019229	regulation of vasoconstriction	IMP	J:95348
Biological Process	GO:0019229	regulation of vasoconstriction	IGI	J:95348
Biological Process	GO:0010996	response to auditory stimulus	IMP	J:279940
Biological Process	GO:1903416	response to glycoside	ISO	J:155856
Biological Process	GO:1903416	response to glycoside	IMP	J:102928
Biological Process	GO:0035094	response to nicotine	ISO	J:155856
Biological Process	GO:0036376	sodium ion export across plasma membrane	ISO	J:164563
Biological Process	GO:0036376	sodium ion export across plasma membrane	IBA	J:265628
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006814	sodium ion transport	ISO	J:155856
Biological Process	GO:0008542	visual learning	IMP	J:117414