GO Annotations Graph

• Symbol: Alox12
• Name: arachidonate 12-lipoxygenase
• ID: MGI:87998

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	IMP	J:276497
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	IDA	J:18190
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	IBA	J:265628
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	IBA	J:265628
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005506	iron ion binding	IEA	J:72247
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity	IMP	J:276497
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:24098
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IBA	J:265628
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:155856
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:164563
Biological Process	GO:0019369	arachidonic acid metabolic process	IMP	J:46896
Biological Process	GO:0019369	arachidonic acid metabolic process	IDA	J:18190
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:55741
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0019395	fatty acid oxidation	IDA	J:277856
Biological Process	GO:0019395	fatty acid oxidation	ISO	J:164563
Biological Process	GO:0051122	hepoxilin biosynthetic process	ISO	J:155856
Biological Process	GO:0043651	linoleic acid metabolic process	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	ISO	J:164563
Biological Process	GO:0034440	lipid oxidation	IBA	J:265628
Biological Process	GO:2001303	lipoxin A4 biosynthetic process	ISO	J:164563
Biological Process	GO:2001306	lipoxin B4 biosynthetic process	ISO	J:164563
Biological Process	GO:0019372	lipoxygenase pathway	IDA	J:18190
Biological Process	GO:0019372	lipoxygenase pathway	IMP	J:46896
Biological Process	GO:0019372	lipoxygenase pathway	ISO	J:155856
Biological Process	GO:0019372	lipoxygenase pathway	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:0090331	negative regulation of platelet aggregation	IMP	J:46896
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:155856
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:1905956	positive regulation of endothelial tube morphogenesis	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0051901	positive regulation of mitochondrial depolarization	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0033559	unsaturated fatty acid metabolic process	ISO	J:164563