Abl1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
MGI:87859

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051015	actin filament binding	IDA	J:75087
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IDA	J:116399
Molecular Function	GO:0000405	bubble DNA binding	ISO	J:164563
Molecular Function	GO:0070097	delta-catenin binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:214156
Molecular Function	GO:0000400	four-way junction DNA binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IDA	J:80705
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:116399
Molecular Function	GO:0030145	manganese ion binding	IDA	J:116399
Molecular Function	GO:0030145	manganese ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	ISO	J:164563
Molecular Function	GO:0038191	neuropilin binding	ISO	J:164563
Molecular Function	GO:0038191	neuropilin binding	IPI	J:214295
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0070064	proline-rich region binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:197520
Molecular Function	GO:0005515	protein binding	IPI	J:232550
Molecular Function	GO:0005515	protein binding	IPI	J:200513
Molecular Function	GO:0005515	protein binding	IPI	J:91138
Molecular Function	GO:0005515	protein binding	IPI	J:91138
Molecular Function	GO:0005515	protein binding	IPI	J:201300
Molecular Function	GO:0005515	protein binding	IPI	J:151442
Molecular Function	GO:0005515	protein binding	IPI	J:175086
Molecular Function	GO:0005515	protein binding	IPI	J:210101
Molecular Function	GO:0005515	protein binding	IPI	J:120363
Molecular Function	GO:0005515	protein binding	IPI	J:58605
Molecular Function	GO:0005515	protein binding	IPI	J:44192
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:57558
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:57558
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:57558
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	IMP	J:214295
Molecular Function	GO:0004672	protein kinase activity	IDA	J:83872
Molecular Function	GO:0004672	protein kinase activity	IDA	J:75087
Molecular Function	GO:0004672	protein kinase activity	ISO	J:73065
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:164563
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:175114
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:116399
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:196110
Molecular Function	GO:0004713	protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:140959
Molecular Function	GO:0004713	protein tyrosine kinase activity	IGI	J:164680
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:172188
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:166211
Molecular Function	GO:0004713	protein tyrosine kinase activity	IGI	J:164680
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:78428
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:115336
Molecular Function	GO:0004713	protein tyrosine kinase activity	IGI	J:140959
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:73065
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:73065
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:164352
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:190676
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:161969
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:85464
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:190763
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0019905	syntaxin binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0015629	actin cytoskeleton	IDA	J:75087
Cellular Component	GO:0031252	cell leading edge	IDA	J:161969
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:116366
Cellular Component	GO:0005737	cytoplasm	IDA	J:75087
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1013873
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-449198
Cellular Component	GO:0005829	cytosol	ISA	J:117719
Cellular Component	GO:0005829	cytosol	ISO	J:73065
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:73065
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:73065
Cellular Component	GO:0005730	nucleolus	ISO	J:73065
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:116366
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:32537
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0001726	ruffle	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0030036	actin cytoskeleton organization	IDA	J:116356
Biological Process	GO:0030041	actin filament polymerization	ISO	J:155856
Biological Process	GO:0050798	activated T cell proliferation	IMP	J:154821
Biological Process	GO:1990051	activation of protein kinase C activity	ISO	J:164563
Biological Process	GO:0046632	alpha-beta T cell differentiation	IGI	J:154821
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0042100	B cell proliferation	IMP	J:147102
Biological Process	GO:0002322	B cell proliferation involved in immune response	IGI	J:28795
Biological Process	GO:0002322	B cell proliferation involved in immune response	IMP	J:66085
Biological Process	GO:0002322	B cell proliferation involved in immune response	IMP	J:34903
Biological Process	GO:0050853	B cell receptor signaling pathway	IMP	J:147102
Biological Process	GO:0050853	B cell receptor signaling pathway	IMP	J:66085
Biological Process	GO:0001922	B-1 B cell homeostasis	IMP	J:147102
Biological Process	GO:0060020	Bergmann glial cell differentiation	IGI	J:166211
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:190763
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:211130
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:211130
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:34903
Biological Process	GO:0090398	cellular senescence	IGI	J:190763
Biological Process	GO:0021587	cerebellum morphogenesis	IGI	J:166211
Biological Process	GO:0072359	circulatory system development	IGI	J:51887
Biological Process	GO:1904157	DN4 thymocyte differentiation	IGI	J:154821
Biological Process	GO:0071103	DNA conformation change	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0043542	endothelial cell migration	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:140959
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:140959
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:190763
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:190676
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:186633
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:154821
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0032623	interleukin-2 production	IGI	J:154821
Biological Process	GO:0007611	learning or memory	ISO	J:155856
Biological Process	GO:0030035	microspike assembly	IDA	J:75087
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IMP	J:190763
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	IGI	J:211130
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	IGI	J:211130
Biological Process	GO:2000773	negative regulation of cellular senescence	IGI	J:190763
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	IGI	J:198786
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:190763
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:153689
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	IGI	J:214156
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	IGI	J:32537
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	IGI	J:32537
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	IDA	J:32537
Biological Process	GO:1900275	negative regulation of phospholipase C activity	ISO	J:73065
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	ISO	J:73065
Biological Process	GO:0001843	neural tube closure	IGI	J:51887
Biological Process	GO:0060563	neuroepithelial cell differentiation	IGI	J:51887
Biological Process	GO:0050885	neuromuscular process controlling balance	IGI	J:166211
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:164352
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:164352
Biological Process	GO:0030182	neuron differentiation	IGI	J:51887
Biological Process	GO:0038189	neuropilin signaling pathway	ISO	J:164563
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:175114
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:116399
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:161969
Biological Process	GO:0006909	phagocytosis	IMP	J:186633
Biological Process	GO:0006909	phagocytosis	IGI	J:190676
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IDA	J:161969
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP	J:140959
Biological Process	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	ISO	J:164563
Biological Process	GO:1903210	podocyte apoptotic process	ISO	J:155856
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:1904531	positive regulation of actin filament binding	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:153689
Biological Process	GO:1905555	positive regulation of blood vessel branching	IMP	J:214295
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	IDA	J:214295
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:73065
Biological Process	GO:1900006	positive regulation of dendrite development	ISO	J:155856
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:140959
Biological Process	GO:1903905	positive regulation of establishment of T cell polarity	IMP	J:259787
Biological Process	GO:1903055	positive regulation of extracellular matrix organization	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:154821
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IGI	J:154821
Biological Process	GO:1904528	positive regulation of microtubule binding	ISO	J:164563
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	IGI	J:140959
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	IGI	J:140959
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	IMP	J:164352
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	IMP	J:190763
Biological Process	GO:0051353	positive regulation of oxidoreductase activity	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	IGI	J:147102
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:2000406	positive regulation of T cell migration	IMP	J:259787
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:154821
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	IGI	J:164680
Biological Process	GO:0009791	post-embryonic development	IGI	J:51887
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:1904518	protein localization to cytoplasmic microtubule plus-end	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:175086
Biological Process	GO:0006468	protein phosphorylation	IMP	J:214295
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IGI	J:166211
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IGI	J:51887
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IGI	J:166211
Biological Process	GO:0042981	regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0030516	regulation of axon extension	ISO	J:164563
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:74002
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:62221
Biological Process	GO:2000772	regulation of cellular senescence	IGI	J:190763
Biological Process	GO:1903053	regulation of extracellular matrix organization	IGI	J:166211
Biological Process	GO:0031113	regulation of microtubule polymerization	ISO	J:164563
Biological Process	GO:1905244	regulation of modification of synaptic structure	ISO	J:155856
Biological Process	GO:1905244	regulation of modification of synaptic structure	IGI	J:214156
Biological Process	GO:0045580	regulation of T cell differentiation	IMP	J:175086
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	IMP	J:172188
Biological Process	GO:0006979	response to oxidative stress	ISO	J:73065
Biological Process	GO:0042770	signal transduction in response to DNA damage	ISO	J:164563
Biological Process	GO:0048536	spleen development	IMP	J:72875
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	IDA	J:75087
Biological Process	GO:0050852	T cell receptor signaling pathway	IDA	J:137330
Biological Process	GO:0048538	thymus development	IMP	J:72875
Biological Process	GO:0002333	transitional one stage B cell differentiation	IMP	J:147102
Biological Process	GO:0032609	type II interferon production	IGI	J:154821

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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