GO Annotations Graph

• Symbol: Sppl2c
• Name: signal peptide peptidase 2C
• ID: MGI:3045264

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	IDA	J:272982
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	IDA	J:331351
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	IDA	J:328498
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	IBA	J:265628
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	IDA	J:328498
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:328498
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:272982
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:328498
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:331351
Cellular Component	GO:0030660	Golgi-associated vesicle membrane	IBA	J:265628
Cellular Component	GO:0098553	lumenal side of endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:0001675	acrosome assembly	IDA	J:331351
Biological Process	GO:0001675	acrosome assembly	IDA	J:272982
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IDA	J:272982
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	IDA	J:331351
Biological Process	GO:0033619	membrane protein proteolysis	IBA	J:265628
Biological Process	GO:0006508	proteolysis	IEA	J:60000