GO Annotations Graph

• Symbol: Ticam2
• Name: TIR domain containing adaptor molecule 2
• ID: MGI:3040056

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005149	interleukin-1 receptor binding	ISO	J:84379
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0005543	phospholipid binding	IDA	J:133314
Molecular Function	GO:0005515	protein binding	IPI	J:169794
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:84379
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	IDA	J:133314
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0045323	interleukin-1 receptor complex	ISO	J:84379
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0001891	phagocytic cup	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:133314
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IMP	J:222462
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	ISO	J:164563
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	IMP	J:273550
Biological Process	GO:0006909	phagocytosis	ISO	J:164563
Biological Process	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	ISO	J:164563
Biological Process	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	IDA	J:133314
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	ISO	J:164563
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	IMP	J:196619
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:133314
Biological Process	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	IBA	J:265628
Biological Process	GO:0032816	positive regulation of natural killer cell activation	IBA	J:265628
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:196619
Biological Process	GO:0001817	regulation of cytokine production	IMP	J:86256
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:84379
Biological Process	GO:0043330	response to exogenous dsRNA	IBA	J:265628
Biological Process	GO:0070671	response to interleukin-12	IMP	J:196619
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	IBA	J:265628