GO Annotations Graph

• Symbol: Hdac4
• Name: histone deacetylase 4
• ID: MGI:3036234

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:215277
Molecular Function	GO:0003677	DNA binding	IDA	J:102395
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:172910
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:73065
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0030955	potassium ion binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:189792
Molecular Function	GO:0005515	protein binding	IPI	J:169070
Molecular Function	GO:0005515	protein binding	IPI	J:95385
Molecular Function	GO:0005515	protein binding	IPI	J:207816
Molecular Function	GO:0005515	protein binding	IPI	J:123041
Molecular Function	GO:0005515	protein binding	IPI	J:182752
Molecular Function	GO:0005515	protein binding	IPI	J:138150
Molecular Function	GO:0005515	protein binding	IPI	J:94631
Molecular Function	GO:0005515	protein binding	IPI	J:138150
Molecular Function	GO:0005515	protein binding	IPI	J:102395
Molecular Function	GO:0005515	protein binding	IPI	J:136003
Molecular Function	GO:0005515	protein binding	IPI	J:87326
Molecular Function	GO:0005515	protein binding	IPI	J:131022
Molecular Function	GO:0005515	protein binding	IPI	J:99840
Molecular Function	GO:0019901	protein kinase binding	IPI	J:121892
Molecular Function	GO:0033558	protein lysine deacetylase activity	ISO	J:164563
Molecular Function	GO:0033558	protein lysine deacetylase activity	IDA	J:135324
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0019789	SUMO transferase activity	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	IGI	J:99840
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0031672	A band	ISO	J:73065
Cellular Component	GO:0042641	actomyosin	IDA	J:135324
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IMP	J:153383
Cellular Component	GO:0005737	cytoplasm	IDA	J:182752
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:135003
Cellular Component	GO:0000118	histone deacetylase complex	ISO	J:164563
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:128352
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008336
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IMP	J:153383
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:182752
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0030017	sarcomere	ISO	J:155856
Cellular Component	GO:0030017	sarcomere	ISO	J:73065
Cellular Component	GO:0017053	transcription repressor complex	ISO	J:164563
Cellular Component	GO:0030018	Z disc	ISO	J:73065
Biological Process	GO:0008283	cell population proliferation	IMP	J:94631
Biological Process	GO:0008283	cell population proliferation	IDA	J:94631
Biological Process	GO:0006325	chromatin organization	IEA	J:72247
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006338	chromatin remodeling	ISO	J:164563
Biological Process	GO:0040029	epigenetic regulation of gene expression	ISO	J:164563
Biological Process	GO:0016575	histone deacetylation	ISO	J:164563
Biological Process	GO:0070932	histone H3 deacetylation	ISO	J:164563
Biological Process	GO:0070933	histone H4 deacetylation	ISO	J:164563
Biological Process	GO:0070933	histone H4 deacetylation	IBA	J:265628
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:94631
Biological Process	GO:0008285	negative regulation of cell population proliferation	IDA	J:94631
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:102395
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:87326
Biological Process	GO:0045820	negative regulation of glycolytic process	IMP	J:153383
Biological Process	GO:1902894	negative regulation of miRNA transcription	IMP	J:229793
Biological Process	GO:1902894	negative regulation of miRNA transcription	IGI	J:229793
Biological Process	GO:0010832	negative regulation of myotube differentiation	ISO	J:164563
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IMP	J:99840
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:99840
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:128352
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:94631
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:95385
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:119152
Biological Process	GO:0002076	osteoblast development	IMP	J:99840
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:99840
Biological Process	GO:0034983	peptidyl-lysine deacetylation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:153383
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:155856
Biological Process	GO:1902437	positive regulation of male mating behavior	ISO	J:155856
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0033235	positive regulation of protein sumoylation	ISO	J:164563
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:153383
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	ISO	J:164563
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	IMP	J:135324
Biological Process	GO:0043393	regulation of protein binding	ISO	J:164563
Biological Process	GO:0048742	regulation of skeletal muscle fiber development	IGI	J:127416
Biological Process	GO:0048742	regulation of skeletal muscle fiber development	IGI	J:127416
Biological Process	GO:1902809	regulation of skeletal muscle fiber differentiation	IGI	J:127416
Biological Process	GO:1902809	regulation of skeletal muscle fiber differentiation	IGI	J:127416
Biological Process	GO:0014894	response to denervation involved in regulation of muscle adaptation	IMP	J:153383
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0001501	skeletal system development	IMP	J:94631
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	ISO	J:164563