GO Annotations Graph

• Symbol: Elane
• Name: elastase, neutrophil expressed
• ID: MGI:2679229

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019955	cytokine binding	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:73065
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	ISO	J:73065
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0004252	serine-type endopeptidase activity	IDA	J:152360
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:152360
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0030141	secretory granule	ISO	J:73065
Cellular Component	GO:0017053	transcription repressor complex	ISO	J:164563
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	IBA	J:265628
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	IDA	J:152360
Biological Process	GO:0002812	biosynthetic process of antibacterial peptides active against Gram-negative bacteria	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0050832	defense response to fungus	IMP	J:151389
Biological Process	GO:0050832	defense response to fungus	IGI	J:77597
Biological Process	GO:0050832	defense response to fungus	IMP	J:77597
Biological Process	GO:0050900	leukocyte migration	IMP	J:88722
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	ISO	J:155856
Biological Process	GO:0032682	negative regulation of chemokine production	ISO	J:164563
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0070947	neutrophil-mediated killing of fungus	IMP	J:151389
Biological Process	GO:0070945	neutrophil-mediated killing of gram-negative bacterium	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	IBA	J:265628
Biological Process	GO:0006909	phagocytosis	IMP	J:88722
Biological Process	GO:0050778	positive regulation of immune response	IGI	J:77597
Biological Process	GO:0050778	positive regulation of immune response	IMP	J:77597
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:1903238	positive regulation of leukocyte tethering or rolling	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0006508	proteolysis	ISO	J:73065
Biological Process	GO:0032496	response to lipopolysaccharide	IGI	J:77597
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:77597
Biological Process	GO:0009411	response to UV	ISO	J:164563
Biological Process	GO:0001878	response to yeast	IMP	J:151389