GO Annotations Graph

• Symbol: Nlrp12
• Name: NLR family, pyrin domain containing 12
• ID: MGI:2676630

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:304591
Molecular Function	GO:0005515	protein binding	IPI	J:187326
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Biological Process	GO:0071345	cellular response to cytokine stimulus	IBA	J:265628
Biological Process	GO:0071345	cellular response to cytokine stimulus	IMP	J:164725
Biological Process	GO:0071345	cellular response to cytokine stimulus	IMP	J:164725
Biological Process	GO:0036336	dendritic cell migration	IMP	J:164725
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:187326
Biological Process	GO:0001818	negative regulation of cytokine production	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:187326
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:272644
Biological Process	GO:0050728	negative regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0032692	negative regulation of interleukin-1 production	ISO	J:164563
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	IMP	J:187326
Biological Process	GO:0031953	negative regulation of protein autophosphorylation	ISO	J:164563
Biological Process	GO:0009968	negative regulation of signal transduction	ISO	J:164563
Biological Process	GO:0045751	negative regulation of Toll signaling pathway	ISO	J:164563
Biological Process	GO:0038061	NIK/NF-kappaB signaling	IMP	J:187326
Biological Process	GO:0045345	positive regulation of MHC class I biosynthetic process	IBA	J:265628
Biological Process	GO:0045345	positive regulation of MHC class I biosynthetic process	ISO	J:73065
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	IBA	J:265628
Biological Process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:73065
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:73065