GO Annotations Graph

• Symbol: Ago3
• Name: argonaute RISC catalytic subunit 3
• ID: MGI:2446634

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0090624	endoribonuclease activity, cleaving miRNA-paired mRNA	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0035198	miRNA binding	ISO	J:164563
Molecular Function	GO:0035198	miRNA binding	IBA	J:265628
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0003723	RNA binding	IDA	J:150716
Molecular Function	GO:0004521	RNA endonuclease activity	ISO	J:164563
Molecular Function	GO:0004521	RNA endonuclease activity	IBA	J:265628
Molecular Function	GO:0003727	single-stranded RNA binding	ISO	J:164563
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:187588
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0016442	RISC complex	ISO	J:164563
Cellular Component	GO:0016442	RISC complex	IDA	J:150716
Cellular Component	GO:0070578	RISC-loading complex	ISO	J:164563
Biological Process	GO:0035196	miRNA processing	ISO	J:164563
Biological Process	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	ISO	J:164563
Biological Process	GO:0006402	mRNA catabolic process	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:233964
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IMP	J:233964
Biological Process	GO:0031054	pre-miRNA processing	ISO	J:164563
Biological Process	GO:0072091	regulation of stem cell proliferation	ISO	J:164563
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0070922	RISC complex assembly	ISO	J:164563
Biological Process	GO:0010501	RNA secondary structure unwinding	ISO	J:164563
Biological Process	GO:0031047	RNA-mediated gene silencing	IEA	J:72247
Biological Process	GO:0031047	RNA-mediated gene silencing	IEA	J:60000