GO Annotations Graph

• Symbol: Grhl2
• Name: grainyhead like transcription factor 2
• ID: MGI:2182543

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:220468
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISA	J:76635
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:217271
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:167065
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:198884
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISA	J:76635
Molecular Function	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	IDA	J:167065
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:168020
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:217271
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0061713	anterior neural tube closure	IMP	J:174027
Biological Process	GO:0070830	bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0007420	brain development	IBA	J:265628
Biological Process	GO:0007420	brain development	IMP	J:169829
Biological Process	GO:0043010	camera-type eye development	IMP	J:169829
Biological Process	GO:0003208	cardiac ventricle morphogenesis	IMP	J:169829
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0034329	cell junction assembly	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	ISO	J:164563
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:169829
Biological Process	GO:0042733	embryonic digit morphogenesis	IMP	J:169829
Biological Process	GO:0048568	embryonic organ development	IMP	J:169829
Biological Process	GO:0008544	epidermis development	IMP	J:168020
Biological Process	GO:0008544	epidermis development	ISO	J:164563
Biological Process	GO:0003382	epithelial cell morphogenesis	ISO	J:164563
Biological Process	GO:0003382	epithelial cell morphogenesis	IMP	J:198884
Biological Process	GO:0060672	epithelial cell morphogenesis involved in placental branching	IMP	J:220468
Biological Process	GO:0090132	epithelium migration	IMP	J:217271
Biological Process	GO:0060324	face development	IMP	J:169829
Biological Process	GO:0001701	in utero embryonic development	IMP	J:170759
Biological Process	GO:0060487	lung epithelial cell differentiation	IMP	J:217271
Biological Process	GO:0060463	lung lobe morphogenesis	IMP	J:169829
Biological Process	GO:0035264	multicellular organism growth	IMP	J:169829
Biological Process	GO:0045617	negative regulation of keratinocyte differentiation	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	IMP	J:167065
Biological Process	GO:0001843	neural tube closure	IMP	J:164805
Biological Process	GO:0001843	neural tube closure	IMP	J:170759
Biological Process	GO:0021915	neural tube development	IBA	J:265628
Biological Process	GO:0021915	neural tube development	IMP	J:169829
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:217271
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:167065
Biological Process	GO:0044030	regulation of DNA methylation	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISA	J:76635
Biological Process	GO:0010468	regulation of gene expression	IMP	J:169829
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0030323	respiratory tube development	IMP	J:169829