GO Annotations Graph

• Symbol: Gsk3a
• Name: glycogen synthase kinase 3 alpha
• ID: MGI:2152453

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:115106
Molecular Function	GO:0005515	protein binding	IPI	J:162259
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	ISO	J:155856
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IDA	J:183987
Molecular Function	GO:0004672	protein kinase activity	IDA	J:87871
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:201566
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:135361
Molecular Function	GO:0120283	protein serine/threonine kinase binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:162259
Molecular Function	GO:0050321	tau-protein kinase activity	IEA	J:72245
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0030877	beta-catenin destruction complex	NAS	J:319997
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:60000
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	IMP	J:163724
Biological Process	GO:0016477	cell migration	IGI	J:135361
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	IGI	J:162259
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:164563
Biological Process	GO:0036016	cellular response to interleukin-3	IDA	J:201566
Biological Process	GO:0071285	cellular response to lithium ion	IDA	J:99298
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:78619
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IGI	J:162259
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:201566
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IBA	J:265628
Biological Process	GO:0005977	glycogen metabolic process	IEA	J:60000
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:145810
Biological Process	GO:0008286	insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	IMP	J:163724
Biological Process	GO:2000171	negative regulation of dendrite development	ISO	J:155856
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	IMP	J:173141
Biological Process	GO:0046325	negative regulation of glucose import	ISO	J:164563
Biological Process	GO:1904227	negative regulation of glycogen synthase activity, transferring glucose-1-phosphate	ISO	J:164563
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0009968	negative regulation of signal transduction	IEA	J:60000
Biological Process	GO:0032007	negative regulation of TOR signaling	IMP	J:163724
Biological Process	GO:0032007	negative regulation of TOR signaling	IBA	J:265628
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IGI	J:248441
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:135361
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:135361
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0071879	positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IMP	J:163724
Biological Process	GO:0106071	positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:163724
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	IDA	J:183987
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:162259
Biological Process	GO:2000467	positive regulation of glycogen (starch) synthase activity	IMP	J:163724
Biological Process	GO:0045823	positive regulation of heart contraction	IMP	J:163724
Biological Process	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA	J:201566
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	J:135361
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	IDA	J:135361
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:173141
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	J:319997
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	J:201566
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IMP	J:201566
Biological Process	GO:0006468	protein phosphorylation	IDA	J:87871
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	IMP	J:173141
Biological Process	GO:0010975	regulation of neuron projection development	IBA	J:265628
Biological Process	GO:0003073	regulation of systemic arterial blood pressure	IMP	J:163724
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000