GO Annotations Graph

• Symbol: Srd5a2
• Name: steroid 5 alpha-reductase 2
• ID: MGI:2150380

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	ISO	J:155856
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IBA	J:265628
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IMP	J:72807
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IMP	J:91120
Molecular Function	GO:0033218	amide binding	ISO	J:155856
Molecular Function	GO:0047751	cholestenone 5-alpha-reductase activity	IEA	J:72245
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	IEA	J:72247
Molecular Function	GO:0009917	sterol 5-alpha reductase activity	ISO	J:164563
Molecular Function	GO:0030283	testosterone dehydrogenase [NAD(P)] activity	ISO	J:164563
Cellular Component	GO:0070852	cell body fiber	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Biological Process	GO:0006702	androgen biosynthetic process	ISO	J:155856
Biological Process	GO:0006702	androgen biosynthetic process	IMP	J:91120
Biological Process	GO:0008209	androgen metabolic process	ISO	J:155856
Biological Process	GO:0008209	androgen metabolic process	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:72247
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0030539	male genitalia development	IMP	J:72807
Biological Process	GO:0008584	male gonad development	ISO	J:164563
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0043434	response to peptide hormone	ISO	J:155856
Biological Process	GO:0007548	sex differentiation	IEA	J:60000
Biological Process	GO:0006694	steroid biosynthetic process	ISO	J:155856
Biological Process	GO:0006694	steroid biosynthetic process	IBA	J:265628
Biological Process	GO:0006694	steroid biosynthetic process	IMP	J:72807
Biological Process	GO:0006706	steroid catabolic process	ISO	J:155856
Biological Process	GO:0008202	steroid metabolic process	IEA	J:72247
Biological Process	GO:0061370	testosterone biosynthetic process	ISO	J:164563