GO Annotations Graph

• Symbol: Afap1l2
• Name: actin filament associated protein 1-like 2
• ID: MGI:2147658

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:273694
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ISO	J:164563
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0042169	SH2 domain binding	IBA	J:265628
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	IBA	J:265628
Molecular Function	GO:0035591	signaling adaptor activity	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	IBA	J:265628
Biological Process	GO:0032675	regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032675	regulation of interleukin-6 production	IBA	J:265628
Biological Process	GO:0007346	regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0007346	regulation of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0009966	regulation of signal transduction	IEA	J:72247