GO Annotations Graph

• Symbol: Pcsk9
• Name: proprotein convertase subtilisin/kexin type 9
• ID: MGI:2140260

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0034185	apolipoprotein binding	IDA	J:186176
Molecular Function	GO:0034190	apolipoprotein receptor binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0030169	low-density lipoprotein particle binding	IDA	J:186176
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	IDA	J:114949
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISS	J:81825
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:72247
Molecular Function	GO:0030547	signaling receptor inhibitor activity	ISO	J:164563
Molecular Function	GO:0019871	sodium channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0034189	very-low-density lipoprotein particle binding	IDA	J:186176
Molecular Function	GO:0070326	very-low-density lipoprotein particle receptor binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0030134	COPII-coated ER to Golgi transport vesicle	IDA	J:198477
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:198477
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-181788
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IDA	J:81825
Cellular Component	GO:0005615	extracellular space	IDA	J:114949
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:1990667	PCSK9-AnxA2 complex	ISO	J:164563
Cellular Component	GO:1990666	PCSK9-LDLR complex	ISO	J:164563
Cellular Component	GO:1990666	PCSK9-LDLR complex	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:118822
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:0009267	cellular response to starvation	ISO	J:155856
Biological Process	GO:0009267	cellular response to starvation	IDA	J:118822
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	ISS	J:81825
Biological Process	GO:0008203	cholesterol metabolic process	IDA	J:121673
Biological Process	GO:0001822	kidney development	IEP	J:81825
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0042157	lipoprotein metabolic process	IDA	J:121673
Biological Process	GO:0001889	liver development	IEP	J:81825
Biological Process	GO:0032802	low-density lipoprotein particle receptor catabolic process	ISS	J:81825
Biological Process	GO:0032802	low-density lipoprotein particle receptor catabolic process	ISO	J:164563
Biological Process	GO:0032799	low-density lipoprotein receptor particle metabolic process	IDA	J:121673
Biological Process	GO:0007041	lysosomal transport	ISO	J:164563
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:1905596	negative regulation of low-density lipoprotein particle receptor binding	ISO	J:164563
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	ISO	J:164563
Biological Process	GO:0002091	negative regulation of receptor internalization	ISO	J:164563
Biological Process	GO:0001920	negative regulation of receptor recycling	ISO	J:164563
Biological Process	GO:1905601	negative regulation of receptor-mediated endocytosis involved in cholesterol transport	ISO	J:164563
Biological Process	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0022008	neurogenesis	IEP	J:81825
Biological Process	GO:0030182	neuron differentiation	IMP	J:81825
Biological Process	GO:0030182	neuron differentiation	IDA	J:117471
Biological Process	GO:0006644	phospholipid metabolic process	IDA	J:121673
Biological Process	GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISS	J:81825
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:164563
Biological Process	GO:0016540	protein autoprocessing	ISS	J:81825
Biological Process	GO:0016540	protein autoprocessing	ISO	J:164563
Biological Process	GO:0016540	protein autoprocessing	ISO	J:155856
Biological Process	GO:0016485	protein processing	ISO	J:155856
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process	IMP	J:99809
Biological Process	GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process	IMP	J:97836
Biological Process	GO:0043523	regulation of neuron apoptotic process	IMP	J:186215
Biological Process	GO:0010469	regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0006641	triglyceride metabolic process	IDA	J:121673