GO Annotations Graph

• Symbol: Actn1
• Name: actinin, alpha 1
• ID: MGI:2137706

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	IDA	J:221563
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0051015	actin filament binding	IDA	J:93130
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0005519	cytoskeletal regulatory protein binding	ISO	J:155856
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:170947
Molecular Function	GO:0005178	integrin binding	IPI	J:221563
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0030374	nuclear receptor coactivator activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:113949
Molecular Function	GO:0005515	protein binding	IPI	J:114721
Molecular Function	GO:0005515	protein binding	IPI	J:201396
Molecular Function	GO:0005515	protein binding	IPI	J:187422
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:221563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0099186	structural constituent of postsynapse	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0017166	vinculin binding	ISO	J:164563
Molecular Function	GO:0017166	vinculin binding	IDA	J:221563
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0005903	brush border	IDA	J:219622
Cellular Component	GO:0030054	cell junction	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IBA	J:265628
Cellular Component	GO:0042995	cell projection	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IBA	J:265628
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0030864	cortical actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0030864	cortical actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0030863	cortical cytoskeleton	TAS	J:98090
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0032127	dense core granule membrane	TAS	J:114721
Cellular Component	GO:0005916	fascia adherens	IDA	J:73178
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	TAS	J:98090
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0001726	ruffle	IDA	J:119715
Cellular Component	GO:0001726	ruffle	ISO	J:164563
Cellular Component	GO:0030017	sarcomere	IDA	J:210551
Cellular Component	GO:0030141	secretory granule	NAS	J:114721
Cellular Component	GO:0001725	stress fiber	ISO	J:155856
Cellular Component	GO:0001725	stress fiber	ISO	J:164563
Cellular Component	GO:0001725	stress fiber	IDA	J:201396
Cellular Component	GO:0001725	stress fiber	TAS	J:98090
Cellular Component	GO:0030018	Z disc	ISO	J:164563
Cellular Component	GO:0030018	Z disc	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:96468
Cellular Component	GO:0030018	Z disc	IDA	J:158797
Cellular Component	GO:0030018	Z disc	IDA	J:158675
Cellular Component	GO:0030018	Z disc	IDA	J:136004
Biological Process	GO:0030036	actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0051017	actin filament bundle assembly	IDA	J:114721
Biological Process	GO:0051639	actin filament network formation	ISO	J:164563
Biological Process	GO:0007015	actin filament organization	ISO	J:164563
Biological Process	GO:0030865	cortical cytoskeleton organization	TAS	J:98090
Biological Process	GO:0048041	focal adhesion assembly	ISO	J:164563
Biological Process	GO:0055001	muscle cell development	IBA	J:265628
Biological Process	GO:0030220	platelet formation	ISO	J:164563
Biological Process	GO:0036344	platelet morphogenesis	ISO	J:164563