GO Annotations Graph

• Symbol: Nedd4l
• Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
• ID: MGI:1933754

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019870	potassium channel inhibitor activity	ISO	J:155856
Molecular Function	GO:0019870	potassium channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0015459	potassium channel regulator activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:248219
Molecular Function	GO:0005515	protein binding	IPI	J:122283
Molecular Function	GO:0005515	protein binding	IPI	J:122283
Molecular Function	GO:0005515	protein binding	IPI	J:303083
Molecular Function	GO:0005515	protein binding	IPI	J:284781
Molecular Function	GO:0019871	sodium channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0019871	sodium channel inhibitor activity	IBA	J:265628
Molecular Function	GO:0019871	sodium channel inhibitor activity	IDA	J:66806
Molecular Function	GO:0017080	sodium channel regulator activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:303083
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:162486
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:169296
Biological Process	GO:1901380	negative regulation of potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:1901380	negative regulation of potassium ion transmembrane transport	IBA	J:265628
Biological Process	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	ISO	J:155856
Biological Process	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	ISO	J:164563
Biological Process	GO:1902306	negative regulation of sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	IBA	J:265628
Biological Process	GO:0010766	negative regulation of sodium ion transport	IMP	J:148641
Biological Process	GO:0010766	negative regulation of sodium ion transport	IDA	J:126754
Biological Process	GO:0010766	negative regulation of sodium ion transport	IDA	J:66806
Biological Process	GO:0010766	negative regulation of sodium ion transport	ISO	J:73065
Biological Process	GO:0010766	negative regulation of sodium ion transport	IMP	J:169296
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	IMP	J:148641
Biological Process	GO:2001259	positive regulation of cation channel activity	IGI	J:146016
Biological Process	GO:2001288	positive regulation of caveolin-mediated endocytosis	ISO	J:155856
Biological Process	GO:1903861	positive regulation of dendrite extension	ISO	J:164563
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:155856
Biological Process	GO:0010765	positive regulation of sodium ion transport	IGI	J:146016
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0006513	protein monoubiquitination	ISO	J:155856
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:2000810	regulation of bicellular tight junction assembly	IDA	J:162486
Biological Process	GO:0048814	regulation of dendrite morphogenesis	IBA	J:265628
Biological Process	GO:0003254	regulation of membrane depolarization	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:164563
Biological Process	GO:0060306	regulation of membrane repolarization	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	ISO	J:164563
Biological Process	GO:1901016	regulation of potassium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:1902305	regulation of sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0002028	regulation of sodium ion transport	IDA	J:303083
Biological Process	GO:0009651	response to salt stress	IMP	J:148641
Biological Process	GO:0006814	sodium ion transport	IMP	J:169296
Biological Process	GO:0006814	sodium ion transport	IMP	J:169296
Biological Process	GO:0006814	sodium ion transport	IMP	J:148641
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:303083
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	ISO	J:155856