GO Annotations Graph

• Symbol: Egln1
• Name: egl-9 family hypoxia-inducible factor 1
• ID: MGI:1932286

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	ISO	J:73065
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0008198	ferrous iron binding	ISO	J:164563
Molecular Function	GO:0008198	ferrous iron binding	IBA	J:265628
Molecular Function	GO:0005506	iron ion binding	IEA	J:72247
Molecular Function	GO:0031418	L-ascorbic acid binding	IEA	J:60000
Molecular Function	GO:0031418	L-ascorbic acid binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	J:72247
Molecular Function	GO:0031545	peptidyl-proline 4-dioxygenase activity	ISO	J:164563
Molecular Function	GO:0031545	peptidyl-proline 4-dioxygenase activity	IBA	J:265628
Molecular Function	GO:0031543	peptidyl-proline dioxygenase activity	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:234716
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	IDA	J:234716
Cellular Component	GO:0014069	postsynaptic density	IEP	J:234716
Cellular Component	GO:0014069	postsynaptic density	IDA	J:234716
Cellular Component	GO:0014069	postsynaptic density	IDA	J:234716
Cellular Component	GO:0014069	postsynaptic density	IDA	J:234716
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	IMP	J:114669
Biological Process	GO:0071456	cellular response to hypoxia	IBA	J:265628
Biological Process	GO:0060347	heart trabecula formation	IMP	J:114669
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:229447
Biological Process	GO:0032364	intracellular oxygen homeostasis	ISO	J:164563
Biological Process	GO:0060711	labyrinthine layer development	IMP	J:114669
Biological Process	GO:1905290	negative regulation of CAMKK-AMPK signaling cascade	ISO	J:155856
Biological Process	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity	ISO	J:155856
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	ISO	J:164563
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IBA	J:265628
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:229447
Biological Process	GO:0045765	regulation of angiogenesis	IMP	J:180457
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	IDA	J:234716
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	IDA	J:234716
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	IMP	J:234716
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	IMP	J:234716
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	IDA	J:234716
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	IEP	J:234716
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	IDA	J:234716
Biological Process	GO:1901214	regulation of neuron death	IMP	J:229447
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IMP	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IMP	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IEP	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:234716
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0071731	response to nitric oxide	ISO	J:164563
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:114669