GO Annotations Graph

• Symbol: Tsc1
• Name: TSC complex subunit 1
• ID: MGI:1929183

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042030	ATPase inhibitor activity	IMP	J:259136
Molecular Function	GO:0042030	ATPase inhibitor activity	ISO	J:164563
Molecular Function	GO:0030544	Hsp70 protein binding	ISO	J:164563
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:173460
Molecular Function	GO:0005515	protein binding	IPI	J:200369
Molecular Function	GO:0005515	protein binding	IPI	J:139563
Molecular Function	GO:0005515	protein binding	IPI	J:124755
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0005938	cell cortex	ISO	J:164563
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:103933
Cellular Component	GO:0005737	cytoplasm	IDA	J:73510
Cellular Component	GO:0005856	cytoskeleton	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0005811	lipid droplet	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	EXP	J:263419
Cellular Component	GO:0014069	postsynaptic density	IDA	J:263419
Cellular Component	GO:0101031	protein folding chaperone complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0033596	TSC1-TSC2 complex	ISO	J:164563
Cellular Component	GO:0033596	TSC1-TSC2 complex	IBA	J:265628
Biological Process	GO:0090630	activation of GTPase activity	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IMP	J:216437
Biological Process	GO:0008344	adult locomotory behavior	ISO	J:155856
Biological Process	GO:0008306	associative learning	IMP	J:225991
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:70463
Biological Process	GO:0008283	cell population proliferation	IMP	J:70463
Biological Process	GO:0030030	cell projection organization	IMP	J:103933
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	ISO	J:155856
Biological Process	GO:0021987	cerebral cortex development	IMP	J:121858
Biological Process	GO:0009790	embryo development	IMP	J:99796
Biological Process	GO:0046323	glucose import	IMP	J:136406
Biological Process	GO:0021766	hippocampus development	IMP	J:121858
Biological Process	GO:0001822	kidney development	IMP	J:99796
Biological Process	GO:0043379	memory T cell differentiation	IMP	J:216437
Biological Process	GO:0042552	myelination	IMP	J:121858
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	ISO	J:164563
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	IMP	J:259136
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:70463
Biological Process	GO:0045792	negative regulation of cell size	IGI	J:103933
Biological Process	GO:0045792	negative regulation of cell size	IMP	J:104900
Biological Process	GO:0045792	negative regulation of cell size	IMP	J:121858
Biological Process	GO:0045792	negative regulation of cell size	IMP	J:103933
Biological Process	GO:0045792	negative regulation of cell size	IGI	J:104911
Biological Process	GO:0034260	negative regulation of GTPase activity	ISO	J:155856
Biological Process	GO:0016242	negative regulation of macroautophagy	ISO	J:155856
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	ISO	J:155856
Biological Process	GO:0032007	negative regulation of TOR signaling	ISO	J:155856
Biological Process	GO:0032007	negative regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0032007	negative regulation of TOR signaling	IBA	J:265628
Biological Process	GO:0017148	negative regulation of translation	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IMP	J:121858
Biological Process	GO:0001843	neural tube closure	IMP	J:70463
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0016239	positive regulation of macroautophagy	ISO	J:155856
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:155856
Biological Process	GO:0006813	potassium ion transport	IMP	J:116872
Biological Process	GO:0006813	potassium ion transport	IGI	J:116872
Biological Process	GO:0006813	potassium ion transport	IGI	J:116872
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	IMP	J:259136
Biological Process	GO:0051726	regulation of cell cycle	IBA	J:265628
Biological Process	GO:0001952	regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0051893	regulation of focal adhesion assembly	ISO	J:155856
Biological Process	GO:1901214	regulation of neuron death	ISO	J:155856
Biological Process	GO:0043666	regulation of phosphoprotein phosphatase activity	ISO	J:164563
Biological Process	GO:0045859	regulation of protein kinase activity	IGI	J:104911
Biological Process	GO:0051492	regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0006417	regulation of translation	ISO	J:164563
Biological Process	GO:0032868	response to insulin	ISO	J:164563
Biological Process	GO:0006407	rRNA export from nucleus	ISO	J:164563
Biological Process	GO:0050808	synapse organization	IMP	J:103933