GO Annotations Graph

• Symbol: Brsk2
• Name: BR serine/threonine kinase 2
• ID: MGI:1923020

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0000287	magnesium ion binding	IC	J:96030
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:156702
Molecular Function	GO:0005515	protein binding	IPI	J:156702
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	IPI	J:162066
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:96030
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:156702
Molecular Function	GO:0050321	tau-protein kinase activity	IDA	J:96030
Molecular Function	GO:0050321	tau-protein kinase activity	TAS	J:162066
Molecular Function	GO:0050321	tau-protein kinase activity	ISO	J:164563
Molecular Function	GO:0050321	tau-protein kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005813	centrosome	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0150034	distal axon	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0007409	axonogenesis	IMP	J:162066
Biological Process	GO:0007409	axonogenesis	IBA	J:265628
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0036503	ERAD pathway	ISO	J:164563
Biological Process	GO:0030010	establishment of cell polarity	IMP	J:162066
Biological Process	GO:0030010	establishment of cell polarity	IBA	J:265628
Biological Process	GO:0030010	establishment of cell polarity	IGI	J:96030
Biological Process	GO:0030010	establishment of cell polarity	IGI	J:96030
Biological Process	GO:0006887	exocytosis	IEA	J:60000
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0090176	microtubule cytoskeleton organization involved in establishment of planar polarity	IGI	J:259126
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0030182	neuron differentiation	IGI	J:96030
Biological Process	GO:0030182	neuron differentiation	IGI	J:96030
Biological Process	GO:0048812	neuron projection morphogenesis	IGI	J:156702
Biological Process	GO:0048812	neuron projection morphogenesis	IGI	J:156702
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:156702
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0006468	protein phosphorylation	IDA	J:96030
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0050770	regulation of axonogenesis	IGI	J:259126
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:190410
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:164563
Biological Process	GO:0010975	regulation of neuron projection development	IGI	J:259126