GO Annotations Graph

• Symbol: Appl1
• Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
• ID: MGI:1920243

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048487	beta-tubulin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0035091	phosphatidylinositol binding	ISO	J:164563
Molecular Function	GO:0001786	phosphatidylserine binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:226873
Molecular Function	GO:0005515	protein binding	IPI	J:239200
Molecular Function	GO:0005515	protein binding	IPI	J:156351
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0043422	protein kinase B binding	ISO	J:164563
Molecular Function	GO:0043422	protein kinase B binding	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005769	early endosome	IDA	J:239200
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0032009	early phagosome	IDA	J:268015
Cellular Component	GO:0005768	endosome	IDA	J:268015
Cellular Component	GO:0005768	endosome	IDA	J:268007
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0010008	endosome membrane	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:164563
Cellular Component	GO:0097708	intracellular vesicle	ISO	J:164563
Cellular Component	GO:0044354	macropinosome	IDA	J:268007
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0001726	ruffle	IDA	J:268015
Cellular Component	GO:0012506	vesicle membrane	ISO	J:164563
Biological Process	GO:0033211	adiponectin-activated signaling pathway	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	IMP	J:227340
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0008286	insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0099558	maintenance of synapse structure	ISO	J:164563
Biological Process	GO:1905450	negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	IMP	J:268015
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IMP	J:226873
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:164563
Biological Process	GO:1905303	positive regulation of macropinocytosis	IMP	J:268007
Biological Process	GO:0048023	positive regulation of melanin biosynthetic process	ISO	J:164563
Biological Process	GO:0006606	protein import into nucleus	ISO	J:164563
Biological Process	GO:0010762	regulation of fibroblast migration	IMP	J:227340
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0046324	regulation of glucose import	ISO	J:164563
Biological Process	GO:0045088	regulation of innate immune response	IMP	J:268007
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0034143	regulation of toll-like receptor 4 signaling pathway	IMP	J:268007
Biological Process	GO:0023052	signaling	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563