P2ry12 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

P2ry12
purinergic receptor P2Y, G-protein coupled 12
MGI:1918089

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IMP	J:70017
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	ISO	J:164563
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	ISO	J:155856
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	IMP	J:70017
Molecular Function	GO:0045028	G protein-coupled purinergic nucleotide receptor activity	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0044298	cell body membrane	IGI	J:236506
Cellular Component	GO:0031253	cell projection membrane	IGI	J:236506
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:116110
Cellular Component	GO:0005886	plasma membrane	IC	J:70017
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP	J:70017
Biological Process	GO:0007596	blood coagulation	IEA	J:60000
Biological Process	GO:0007596	blood coagulation	IEA	J:72247
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:155856
Biological Process	GO:0035585	calcium-mediated signaling using extracellular calcium source	ISO	J:155856
Biological Process	GO:0030030	cell projection organization	ISO	J:155856
Biological Process	GO:0071318	cellular response to ATP	ISO	J:155856
Biological Process	GO:0071318	cellular response to ATP	IMP	J:116110
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:194901
Biological Process	GO:0021808	cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration	ISO	J:155856
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:118491
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:118491
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	IMP	J:70017
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IMP	J:70017
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008347	glial cell migration	ISO	J:155856
Biological Process	GO:0007599	hemostasis	IEA	J:60000
Biological Process	GO:0030032	lamellipodium assembly	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0045596	negative regulation of cell differentiation	ISO	J:155856
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	ISO	J:155856
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0030168	platelet activation	IMP	J:70017
Biological Process	GO:0070527	platelet aggregation	ISO	J:164563
Biological Process	GO:0070527	platelet aggregation	ISO	J:155856
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	ISO	J:155856
Biological Process	GO:0050921	positive regulation of chemotaxis	ISO	J:155856
Biological Process	GO:0033626	positive regulation of integrin activation by cell surface receptor linked signal transduction	ISO	J:155856
Biological Process	GO:1904141	positive regulation of microglial cell migration	ISO	J:155856
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	IGI	J:118491
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	IGI	J:118491
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:1900029	positive regulation of ruffle assembly	ISO	J:155856
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:155856
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0050920	regulation of chemotaxis	ISO	J:155856
Biological Process	GO:1904139	regulation of microglial cell migration	IDA	J:116110
Biological Process	GO:0048678	response to axon injury	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	IMP	J:116110
Biological Process	GO:0150063	visual system development	IGI	J:236506

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23