GO Annotations Graph

• Symbol: Pkp2
• Name: plakophilin 2
• ID: MGI:1914701

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045294	alpha-catenin binding	ISO	J:164563
Molecular Function	GO:0045294	alpha-catenin binding	IBA	J:265628
Molecular Function	GO:0045296	cadherin binding	IBA	J:265628
Molecular Function	GO:0019215	intermediate filament binding	ISO	J:164563
Molecular Function	GO:0019215	intermediate filament binding	IBA	J:265628
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:124009
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	IBA	J:265628
Cellular Component	GO:0005912	adherens junction	ISO	J:155856
Cellular Component	GO:0005912	adherens junction	IBA	J:265628
Cellular Component	GO:0030054	cell junction	ISO	J:155856
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:170926
Cellular Component	GO:0005911	cell-cell junction	IMP	J:93314
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0030057	desmosome	ISO	J:164563
Cellular Component	GO:0030057	desmosome	IDA	J:181275
Cellular Component	GO:0030057	desmosome	IDA	J:51903
Cellular Component	GO:0014704	intercalated disc	ISO	J:155856
Cellular Component	GO:0014704	intercalated disc	ISO	J:164563
Cellular Component	GO:0014704	intercalated disc	IBA	J:265628
Cellular Component	GO:0014704	intercalated disc	IDA	J:124009
Cellular Component	GO:0005882	intermediate filament	IDA	J:125067
Cellular Component	GO:0005882	intermediate filament	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0034334	adherens junction maintenance	ISO	J:155856
Biological Process	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	ISO	J:164563
Biological Process	GO:0086001	cardiac muscle cell action potential	ISO	J:155856
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0098609	cell-cell adhesion	IBA	J:265628
Biological Process	GO:0098609	cell-cell adhesion	IMP	J:93314
Biological Process	GO:0007043	cell-cell junction assembly	IBA	J:265628
Biological Process	GO:0086019	cell-cell signaling involved in cardiac conduction	ISO	J:164563
Biological Process	GO:0086019	cell-cell signaling involved in cardiac conduction	IBA	J:265628
Biological Process	GO:0002159	desmosome assembly	ISO	J:164563
Biological Process	GO:0002934	desmosome organization	IBA	J:265628
Biological Process	GO:0016264	gap junction assembly	ISO	J:155856
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:93314
Biological Process	GO:0007507	heart development	IMP	J:93314
Biological Process	GO:0045110	intermediate filament bundle assembly	ISO	J:164563
Biological Process	GO:0045110	intermediate filament bundle assembly	IBA	J:265628
Biological Process	GO:0055088	lipid homeostasis	ISO	J:155856
Biological Process	GO:0048496	maintenance of animal organ identity	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	IBA	J:265628
Biological Process	GO:2000810	regulation of bicellular tight junction assembly	ISO	J:155856
Biological Process	GO:0010810	regulation of cell-substrate adhesion	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:1900024	regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	ISO	J:164563