GO Annotations Graph

• Symbol: Otof
• Name: otoferlin
• ID: MGI:1891247

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0035612	AP-2 adaptor complex binding	IBA	J:265628
Molecular Function	GO:0035612	AP-2 adaptor complex binding	IDA	J:198657
Molecular Function	GO:0005509	calcium ion binding	IDA	J:116097
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:116097
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0045178	basal part of cell	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0060203	clathrin-sculpted glutamate transport vesicle membrane	TAS	Reactome:R-MMU-9664156
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:237954
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0048787	presynaptic active zone membrane	IBA	J:265628
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:223843
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0030672	synaptic vesicle membrane	IDA	J:116097
Cellular Component	GO:0030672	synaptic vesicle membrane	IBA	J:265628
Biological Process	GO:0007009	plasma membrane organization	IBA	J:265628
Biological Process	GO:0007605	sensory perception of sound	ISO	J:237954
Biological Process	GO:0001964	startle response	ISO	J:237954
Biological Process	GO:0016079	synaptic vesicle exocytosis	IDA	J:131715
Biological Process	GO:0016079	synaptic vesicle exocytosis	IMP	J:116097
Biological Process	GO:0016079	synaptic vesicle exocytosis	IMP	J:223843
Biological Process	GO:0016082	synaptic vesicle priming	IMP	J:161797
Biological Process	GO:0016082	synaptic vesicle priming	IBA	J:265628