GO Annotations Graph

• Symbol: Fzd2
• Name: frizzled class receptor 2
• ID: MGI:1888513

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:323230
Molecular Function	GO:0005515	protein binding	IPI	J:89972
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:155856
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Molecular Function	GO:0042813	Wnt receptor activity	ISO	J:155856
Molecular Function	GO:0042813	Wnt receptor activity	ISO	J:164563
Molecular Function	GO:0042813	Wnt receptor activity	IBA	J:265628
Molecular Function	GO:0042813	Wnt receptor activity	IDA	J:161589
Molecular Function	GO:0017147	Wnt-protein binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007267	cell-cell signaling	IDA	J:98305
Biological Process	GO:0007267	cell-cell signaling	IDA	J:98305
Biological Process	GO:0090103	cochlea morphogenesis	IGI	J:165556
Biological Process	GO:0045446	endothelial cell differentiation	IDA	J:98305
Biological Process	GO:0045446	endothelial cell differentiation	IGI	J:98305
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007199	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	ISO	J:155856
Biological Process	GO:0060022	hard palate development	IGI	J:165556
Biological Process	GO:0060022	hard palate development	IMP	J:165556
Biological Process	GO:0060119	inner ear receptor cell development	IGI	J:165556
Biological Process	GO:0003149	membranous septum morphogenesis	IGI	J:165556
Biological Process	GO:0003149	membranous septum morphogenesis	IGI	J:165556
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0003150	muscular septum morphogenesis	IGI	J:165556
Biological Process	GO:0003150	muscular septum morphogenesis	IGI	J:165556
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:165556
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:165556
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:165556
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0007608	sensory perception of smell	IMP	J:165556
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0060412	ventricular septum morphogenesis	IGI	J:165556
Biological Process	GO:0016055	Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0007223	Wnt signaling pathway, calcium modulating pathway	ISO	J:155856