GO Annotations Graph

• Symbol: Dkc1
• Name: dyskeratosis congenita 1, dyskerin
• ID: MGI:1861727

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0034513	box H/ACA snoRNA binding	ISO	J:164563
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:199000
Molecular Function	GO:0009982	pseudouridine synthase activity	ISO	J:164563
Molecular Function	GO:0009982	pseudouridine synthase activity	IBA	J:265628
Molecular Function	GO:0003723	RNA binding	ISO	J:164563
Molecular Function	GO:0003720	telomerase activity	ISO	J:164563
Molecular Function	GO:0003720	telomerase activity	ISO	J:164563
Molecular Function	GO:0070034	telomerase RNA binding	ISO	J:164563
Cellular Component	GO:0031429	box H/ACA snoRNP complex	ISO	J:164563
Cellular Component	GO:0031429	box H/ACA snoRNP complex	ISO	J:155856
Cellular Component	GO:0031429	box H/ACA snoRNP complex	IBA	J:265628
Cellular Component	GO:0090661	box H/ACA telomerase RNP complex	ISO	J:164563
Cellular Component	GO:0015030	Cajal body	ISO	J:155856
Cellular Component	GO:0015030	Cajal body	IDA	J:198728
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	IDA	J:198728
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005697	telomerase holoenzyme complex	ISO	J:164563
Cellular Component	GO:0005697	telomerase holoenzyme complex	NAS	J:320115
Biological Process	GO:0000495	box H/ACA RNA 3'-end processing	IBA	J:265628
Biological Process	GO:0033979	box H/ACA RNA metabolic process	IMP	J:198728
Biological Process	GO:0000455	enzyme-directed rRNA pseudouridine synthesis	ISO	J:164563
Biological Process	GO:1990481	mRNA pseudouridine synthesis	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:1904851	positive regulation of establishment of protein localization to telomere	ISO	J:164563
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:0051973	positive regulation of telomerase activity	IMP	J:91485
Biological Process	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	ISO	J:164563
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	IMP	J:91485
Biological Process	GO:0001522	pseudouridine synthesis	IEA	J:72247
Biological Process	GO:1904872	regulation of telomerase RNA localization to Cajal body	ISO	J:164563
Biological Process	GO:0042254	ribosome biogenesis	IEA	J:60000
Biological Process	GO:0009451	RNA modification	IEA	J:72247
Biological Process	GO:0006396	RNA processing	IEA	J:72247
Biological Process	GO:0006364	rRNA processing	IEA	J:60000
Biological Process	GO:0031118	rRNA pseudouridine synthesis	IBA	J:265628
Biological Process	GO:0031118	rRNA pseudouridine synthesis	IMP	J:91485
Biological Process	GO:0031118	rRNA pseudouridine synthesis	IMP	J:91485
Biological Process	GO:0031118	rRNA pseudouridine synthesis	IMP	J:198728
Biological Process	GO:0090666	scaRNA localization to Cajal body	ISO	J:164563
Biological Process	GO:0000454	snoRNA guided rRNA pseudouridine synthesis	ISO	J:155856
Biological Process	GO:0031120	snRNA pseudouridine synthesis	IBA	J:265628
Biological Process	GO:0090669	telomerase RNA stabilization	ISO	J:164563
Biological Process	GO:0007004	telomere maintenance via telomerase	NAS	J:320115
Biological Process	GO:0007004	telomere maintenance via telomerase	ISO	J:164563