GO Annotations Graph

• Symbol: Dll4
• Name: delta like canonical Notch ligand 4
• ID: MGI:1859388

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0005112	Notch binding	ISO	J:164563
Molecular Function	GO:0005112	Notch binding	IBA	J:265628
Molecular Function	GO:0005112	Notch binding	IPI	J:167379
Molecular Function	GO:0005112	Notch binding	IDA	J:62507
Molecular Function	GO:0005515	protein binding	IPI	J:227382
Molecular Function	GO:0005515	protein binding	IPI	J:101173
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2053938
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9604278
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISS	J:62507
Biological Process	GO:0001525	angiogenesis	IMP	J:93125
Biological Process	GO:0001525	angiogenesis	IMP	J:200671
Biological Process	GO:0003180	aortic valve morphogenesis	ISO	J:164563
Biological Process	GO:0072554	blood vessel lumenization	IMP	J:93125
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:93125
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:93157
Biological Process	GO:0003209	cardiac atrium morphogenesis	IMP	J:93157
Biological Process	GO:0003208	cardiac ventricle morphogenesis	IMP	J:93157
Biological Process	GO:0007154	cell communication	IEA	J:72247
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0035912	dorsal aorta morphogenesis	IMP	J:93157
Biological Process	GO:0035912	dorsal aorta morphogenesis	IMP	J:93125
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	IDA	J:138721
Biological Process	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010596	negative regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IDA	J:224861
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:93157
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0061314	Notch signaling involved in heart development	IMP	J:93157
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	IBA	J:265628
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:212472
Biological Process	GO:0003344	pericardium morphogenesis	IMP	J:93157
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	IMP	J:181993
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IDA	J:224861
Biological Process	GO:0061074	regulation of neural retina development	IMP	J:181993
Biological Process	GO:0050767	regulation of neurogenesis	IMP	J:149456
Biological Process	GO:0050896	response to stimulus	IEA	J:60000
Biological Process	GO:0030217	T cell differentiation	IDA	J:90630
Biological Process	GO:0060579	ventral spinal cord interneuron fate commitment	ISO	J:164563
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	IMP	J:93157
Biological Process	GO:0007601	visual perception	IEA	J:60000