GO Annotations Graph

• Symbol: Spast
• Name: spastin
• ID: MGI:1858896

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043014	alpha-tubulin binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016887	ATP hydrolysis activity	IEA	J:72247
Molecular Function	GO:0048487	beta-tubulin binding	ISO	J:164563
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	ISO	J:164563
Molecular Function	GO:0008568	microtubule severing ATPase activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:73065
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0071782	endoplasmic reticulum tubular network	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005811	lipid droplet	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	IEA	J:60000
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0015630	microtubule cytoskeleton	IBA	J:265628
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:162689
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:80914
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0000922	spindle pole	ISO	J:164563
Biological Process	GO:0008089	anterograde axonal transport	IMP	J:148877
Biological Process	GO:0019896	axonal transport of mitochondrion	IMP	J:148877
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0032506	cytokinetic process	ISO	J:164563
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	ISO	J:164563
Biological Process	GO:0010458	exit from mitosis	ISO	J:164563
Biological Process	GO:0090148	membrane fission	ISO	J:164563
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0001578	microtubule bundle formation	ISO	J:164563
Biological Process	GO:0051013	microtubule severing	ISO	J:164563
Biological Process	GO:0051013	microtubule severing	IGI	J:162689
Biological Process	GO:0051013	microtubule severing	IMP	J:162689
Biological Process	GO:0051013	microtubule severing	IDA	J:162689
Biological Process	GO:0051013	microtubule severing	IGI	J:162689
Biological Process	GO:0000281	mitotic cytokinesis	ISO	J:164563
Biological Process	GO:0051228	mitotic spindle disassembly	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0031468	nuclear membrane reassembly	ISO	J:164563
Biological Process	GO:0032467	positive regulation of cytokinesis	ISO	J:164563
Biological Process	GO:0034214	protein hexamerization	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563