GO Annotations Graph

• Symbol: Icosl
• Name: icos ligand
• ID: MGI:1354701

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:60318
Molecular Function	GO:0005515	protein binding	IPI	J:61649
Molecular Function	GO:0005102	signaling receptor binding	TAS	J:114030
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:60318
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:61649
Cellular Component	GO:0016020	membrane	NAS	J:87124
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:60318
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0042113	B cell activation	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045190	isotype switching	NAS	J:87124
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	TAS	J:114030
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IMP	J:66702
Biological Process	GO:0001817	regulation of cytokine production	IBA	J:265628
Biological Process	GO:0007165	signal transduction	NAS	J:87124
Biological Process	GO:0042110	T cell activation	NAS	J:87124
Biological Process	GO:0050852	T cell receptor signaling pathway	IBA	J:265628