GO Annotations Graph

• Symbol: Nr4a2
• Name: nuclear receptor subfamily 4, group A, member 2
• ID: MGI:1352456

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:88146
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:210935
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:222687
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:210935
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IEA	J:72247
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	IPI	J:222154
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	IBA	J:265628
Molecular Function	GO:0004879	nuclear receptor activity	TAS	J:39661
Molecular Function	GO:0005515	protein binding	IPI	J:150472
Molecular Function	GO:0005515	protein binding	IPI	J:156994
Molecular Function	GO:0005515	protein binding	IPI	J:222151
Molecular Function	GO:0005515	protein binding	IPI	J:144189
Molecular Function	GO:0005515	protein binding	IPI	J:88146
Molecular Function	GO:0005515	protein binding	IPI	J:137305
Molecular Function	GO:0005515	protein binding	IPI	J:141260
Molecular Function	GO:0005515	protein binding	IPI	J:222687
Molecular Function	GO:0005515	protein binding	IPI	J:37081
Molecular Function	GO:0005515	protein binding	IPI	J:141260
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:222687
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:150356
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP	J:210935
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:37081
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:33226
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-4755534
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:73864
Cellular Component	GO:0005634	nucleus	IDA	J:136893
Cellular Component	GO:0005634	nucleus	IDA	J:136893
Cellular Component	GO:0005667	transcription regulator complex	IBA	J:265628
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:96227
Biological Process	GO:0071376	cellular response to corticotropin-releasing hormone stimulus	IDA	J:222687
Biological Process	GO:0071376	cellular response to corticotropin-releasing hormone stimulus	IBA	J:265628
Biological Process	GO:0031668	cellular response to extracellular stimulus	IDA	J:37081
Biological Process	GO:0031668	cellular response to extracellular stimulus	ISO	J:22051
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:162076
Biological Process	GO:0021953	central nervous system neuron differentiation	IBA	J:265628
Biological Process	GO:0021953	central nervous system neuron differentiation	IMP	J:66522
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	IMP	J:58939
Biological Process	GO:0006351	DNA-templated transcription	IDA	J:144189
Biological Process	GO:0006351	DNA-templated transcription	ISO	J:164563
Biological Process	GO:0042416	dopamine biosynthetic process	IMP	J:47684
Biological Process	GO:0042416	dopamine biosynthetic process	IMP	J:128668
Biological Process	GO:0042416	dopamine biosynthetic process	IMP	J:47684
Biological Process	GO:0042417	dopamine metabolic process	IMP	J:96227
Biological Process	GO:0071542	dopaminergic neuron differentiation	TAS	J:227390
Biological Process	GO:0071542	dopaminergic neuron differentiation	IDA	J:144189
Biological Process	GO:0071542	dopaminergic neuron differentiation	IBA	J:265628
Biological Process	GO:0071542	dopaminergic neuron differentiation	IMP	J:66522
Biological Process	GO:0071542	dopaminergic neuron differentiation	IMP	J:89797
Biological Process	GO:0071542	dopaminergic neuron differentiation	IMP	J:46856
Biological Process	GO:0045444	fat cell differentiation	IDA	J:222681
Biological Process	GO:0010467	gene expression	IMP	J:57161
Biological Process	GO:0010467	gene expression	IMP	J:57161
Biological Process	GO:0051866	general adaptation syndrome	IMP	J:96227
Biological Process	GO:0021986	habenula development	IMP	J:154739
Biological Process	GO:0007611	learning or memory	ISO	J:155856
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:162076
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:58939
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IMP	J:73864
Biological Process	GO:0007399	nervous system development	IMP	J:39661
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:58939
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:162076
Biological Process	GO:0030182	neuron differentiation	IMP	J:46856
Biological Process	GO:0030182	neuron differentiation	IMP	J:89797
Biological Process	GO:0042551	neuron maturation	IMP	J:58939
Biological Process	GO:0001764	neuron migration	IMP	J:58939
Biological Process	GO:0043085	positive regulation of catalytic activity	IMP	J:126668
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:37081
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:210935
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:222151
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:222687
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:91558
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:91558
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:122522
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:128668
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:88146
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:128668
Biological Process	GO:0009791	post-embryonic development	IMP	J:47684
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:154739
Biological Process	GO:0042053	regulation of dopamine metabolic process	IDA	J:85047
Biological Process	GO:0010468	regulation of gene expression	IMP	J:150356
Biological Process	GO:0043576	regulation of respiratory gaseous exchange	IMP	J:105253
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0001975	response to amphetamine	IMP	J:96227
Biological Process	GO:0001666	response to hypoxia	IMP	J:105253
Biological Process	GO:0010035	response to inorganic substance	ISO	J:33283
Biological Process	GO:0017085	response to insecticide	ISO	J:33226
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:128668