GO Annotations Graph

• Symbol: Pkd2l1
• Name: polycystic kidney disease 2-like 1
• ID: MGI:1352448

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051393	alpha-actinin binding	ISO	J:164563
Molecular Function	GO:0005227	calcium activated cation channel activity	ISO	J:164563
Molecular Function	GO:0005262	calcium channel activity	IMP	J:207901
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0005262	calcium channel activity	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	IDA	J:182478
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0015269	calcium-activated potassium channel activity	ISO	J:164563
Molecular Function	GO:0015269	calcium-activated potassium channel activity	IBA	J:265628
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:182388
Molecular Function	GO:0042802	identical protein binding	IPI	J:182478
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005261	monoatomic cation channel activity	IDA	J:182388
Molecular Function	GO:0005261	monoatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0005261	monoatomic cation channel activity	IDA	J:266474
Molecular Function	GO:0005261	monoatomic cation channel activity	IPI	J:96951
Molecular Function	GO:0008324	monoatomic cation transmembrane transporter activity	IDA	J:182388
Molecular Function	GO:0051371	muscle alpha-actinin binding	ISO	J:164563
Molecular Function	GO:0051371	muscle alpha-actinin binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:182388
Molecular Function	GO:0005515	protein binding	IPI	J:96951
Molecular Function	GO:0005272	sodium channel activity	ISO	J:164563
Molecular Function	GO:0005272	sodium channel activity	IBA	J:265628
Molecular Function	GO:0033040	sour taste receptor activity	IDA	J:182388
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0034704	calcium channel complex	IDA	J:283187
Cellular Component	GO:0034704	calcium channel complex	IMP	J:207901
Cellular Component	GO:0034704	calcium channel complex	ISO	J:164563
Cellular Component	GO:0034703	cation channel complex	IDA	J:182388
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	IDA	J:182388
Cellular Component	GO:0005929	cilium	IEA	J:60000
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:96951
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0097730	non-motile cilium	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:266474
Cellular Component	GO:0005886	plasma membrane	IDA	J:283187
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IPI	J:96951
Cellular Component	GO:0043235	receptor complex	IDA	J:182388
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:60000
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0071468	cellular response to acidic pH	IDA	J:283187
Biological Process	GO:0071468	cellular response to acidic pH	IDA	J:182388
Biological Process	GO:0071467	cellular response to pH	IDA	J:266474
Biological Process	GO:0001581	detection of chemical stimulus involved in sensory perception of sour taste	IDA	J:182388
Biological Process	GO:0050912	detection of chemical stimulus involved in sensory perception of taste	IMP	J:244208
Biological Process	GO:0050982	detection of mechanical stimulus	IBA	J:265628
Biological Process	GO:0098662	inorganic cation transmembrane transport	IDA	J:266474
Biological Process	GO:0098662	inorganic cation transmembrane transport	ISO	J:164563
Biological Process	GO:0006812	monoatomic cation transport	IDA	J:182388
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0071805	potassium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0051262	protein tetramerization	IDA	J:283187
Biological Process	GO:0009415	response to water	IMP	J:244208
Biological Process	GO:0050915	sensory perception of sour taste	ISO	J:164563
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:207901
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563