GO Annotations Graph

• Symbol: Grm1
• Name: glutamate receptor, metabotropic 1
• ID: MGI:1351338

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001640	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA	J:265628
Molecular Function	GO:0098872	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	EXP	J:263475
Molecular Function	GO:0098872	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IDA	J:263475
Molecular Function	GO:0098872	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IDA	J:263475
Molecular Function	GO:0098872	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	EXP	J:263475
Molecular Function	GO:0098872	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IDA	J:263475
Molecular Function	GO:0098872	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IDA	J:263475
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	ISO	J:155856
Molecular Function	GO:0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IBA	J:265628
Molecular Function	GO:0008066	glutamate receptor activity	ISO	J:164563
Molecular Function	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IMP	J:151465
Molecular Function	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA	J:265628
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:155856
Molecular Function	GO:0001639	PLC activating G protein-coupled glutamate receptor activity	TAS	J:41096
Molecular Function	GO:0005515	protein binding	IPI	J:101279
Molecular Function	GO:0005515	protein binding	IPI	J:101279
Molecular Function	GO:0005515	protein binding	IPI	J:136341
Molecular Function	GO:0005515	protein binding	IPI	J:50718
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:62729
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0038037	G protein-coupled receptor dimeric complex	ISO	J:164563
Cellular Component	GO:0038038	G protein-coupled receptor homodimeric complex	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263475
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:263475
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263475
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043005	neuron projection	IDA	J:184110
Cellular Component	GO:0043025	neuronal cell body	TAS	J:69456
Cellular Component	GO:0005634	nucleus	IDA	J:101279
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:101279
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	IBA	J:265628
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	TAS	J:113903
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:263475
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	EXP	J:263475
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:263475
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:155856
Biological Process	GO:0071257	cellular response to electrical stimulus	IMP	J:166679
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0098712	L-glutamate import across plasma membrane	IDA	J:96918
Biological Process	GO:0007626	locomotory behavior	IMP	J:62729
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:69456
Biological Process	GO:0051930	regulation of sensory perception of pain	IDA	J:69456
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	IBA	J:265628
Biological Process	GO:0019233	sensory perception of pain	IMP	J:69456
Biological Process	GO:0007165	signal transduction	IEA	J:60000