GO Annotations Graph

• Symbol: Fto
• Name: FTO alpha-ketoglutarate dependent dioxygenase
• ID: MGI:1347093

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0043734	DNA-N1-methyladenine dioxygenase activity	IDA	J:157439
Molecular Function	GO:0043734	DNA-N1-methyladenine dioxygenase activity	ISO	J:164563
Molecular Function	GO:0043734	DNA-N1-methyladenine dioxygenase activity	IBA	J:265628
Molecular Function	GO:0008198	ferrous iron binding	ISO	J:164563
Molecular Function	GO:0008198	ferrous iron binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:1990931	mRNA N6-methyladenosine dioxygenase activity	ISO	J:164563
Molecular Function	GO:1990931	mRNA N6-methyladenosine dioxygenase activity	IBA	J:265628
Molecular Function	GO:0035516	oxidative DNA demethylase activity	ISO	J:164563
Molecular Function	GO:0035516	oxidative DNA demethylase activity	IDA	J:141150
Molecular Function	GO:0035516	oxidative DNA demethylase activity	IBA	J:265628
Molecular Function	GO:0035515	oxidative RNA demethylase activity	IDA	J:141150
Molecular Function	GO:0035515	oxidative RNA demethylase activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:1990984	tRNA demethylase activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:157439
Cellular Component	GO:0005634	nucleus	IDA	J:147471
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0060612	adipose tissue development	IMP	J:147471
Biological Process	GO:0006307	DNA dealkylation involved in DNA repair	IDA	J:141150
Biological Process	GO:0006307	DNA dealkylation involved in DNA repair	ISO	J:164563
Biological Process	GO:0080111	DNA demethylation	IDA	J:141150
Biological Process	GO:0080111	DNA demethylation	ISO	J:164563
Biological Process	GO:0080111	DNA demethylation	IDA	J:157439
Biological Process	GO:0061157	mRNA destabilization	ISO	J:164563
Biological Process	GO:0070989	oxidative demethylation	ISO	J:164563
Biological Process	GO:0070989	oxidative demethylation	IDA	J:141150
Biological Process	GO:0035552	oxidative single-stranded DNA demethylation	IDA	J:141150
Biological Process	GO:0035552	oxidative single-stranded DNA demethylation	ISO	J:164563
Biological Process	GO:0035552	oxidative single-stranded DNA demethylation	IBA	J:265628
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	ISO	J:164563
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	IDA	J:141150
Biological Process	GO:0035553	oxidative single-stranded RNA demethylation	IBA	J:265628
Biological Process	GO:0090335	regulation of brown fat cell differentiation	ISO	J:164563
Biological Process	GO:0010883	regulation of lipid storage	IMP	J:147471
Biological Process	GO:0010883	regulation of lipid storage	ISO	J:164563
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:147471
Biological Process	GO:0044065	regulation of respiratory system process	IMP	J:147471
Biological Process	GO:0070350	regulation of white fat cell proliferation	IMP	J:147471
Biological Process	GO:0042245	RNA repair	IDA	J:141150
Biological Process	GO:0042245	RNA repair	ISO	J:164563
Biological Process	GO:0001659	temperature homeostasis	IMP	J:147471