GO Annotations Graph

• Symbol: Mapk3
• Name: mitogen-activated protein kinase 3
• ID: MGI:1346859

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004707	MAP kinase activity	ISO	J:164563
Molecular Function	GO:0004707	MAP kinase activity	ISO	J:155856
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:31517
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:31517
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:92782
Molecular Function	GO:0004707	MAP kinase activity	IMP	J:75391
Molecular Function	GO:0004707	MAP kinase activity	TAS	J:72305
Molecular Function	GO:0004708	MAP kinase kinase activity	IMP	J:228528
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	IMP	J:86622
Molecular Function	GO:0005515	protein binding	IPI	J:245256
Molecular Function	GO:0005515	protein binding	IPI	J:86622
Molecular Function	GO:0005515	protein binding	IPI	J:93997
Molecular Function	GO:0005515	protein binding	IPI	J:117524
Molecular Function	GO:0004672	protein kinase activity	IDA	J:93432
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-198706
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005901	caveola	TAS	J:180564
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:79147
Cellular Component	GO:0005737	cytoplasm	IDA	J:74534
Cellular Component	GO:0005856	cytoskeleton	TAS	J:180564
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	J:180564
Cellular Component	GO:0005829	cytosol	IDA	J:193006
Cellular Component	GO:0005769	early endosome	TAS	J:180564
Cellular Component	GO:0005925	focal adhesion	TAS	J:180564
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:89788
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:89788
Cellular Component	GO:0005794	Golgi apparatus	TAS	J:180564
Cellular Component	GO:0005770	late endosome	TAS	J:180564
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	TAS	J:180564
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-198706
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	TAS	J:180564
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:74534
Cellular Component	GO:0005634	nucleus	IDA	J:68671
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0031143	pseudopodium	IDA	J:85273
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0009887	animal organ morphogenesis	IDA	J:72305
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0060020	Bergmann glial cell differentiation	IGI	J:205567
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0061308	cardiac neural crest cell development involved in heart development	IGI	J:144862
Biological Process	GO:0051216	cartilage development	IDA	J:125386
Biological Process	GO:0072584	caveolin-mediated endocytosis	TAS	J:180564
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0071276	cellular response to cadmium ion	ISO	J:164563
Biological Process	GO:1903351	cellular response to dopamine	ISO	J:164563
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IGI	J:211147
Biological Process	GO:0046697	decidualization	ISO	J:155856
Biological Process	GO:0006974	DNA damage response	IDA	J:93432
Biological Process	GO:0006351	DNA-templated transcription	IMP	J:135485
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:143745
Biological Process	GO:0060324	face development	IGI	J:144862
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:166544
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:327219
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:327218
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:84896
Biological Process	GO:0060425	lung morphogenesis	IGI	J:214083
Biological Process	GO:0000165	MAPK cascade	ISO	J:155856
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:89788
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:89788
Biological Process	GO:2000657	negative regulation of apolipoprotein binding	IMP	J:161670
Biological Process	GO:0014032	neural crest cell development	IGI	J:144862
Biological Process	GO:0042473	outer ear morphogenesis	IGI	J:144862
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	TAS	J:79147
Biological Process	GO:0031281	positive regulation of cyclase activity	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	ISO	J:164563
Biological Process	GO:0120041	positive regulation of macrophage proliferation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:1904355	positive regulation of telomere capping	ISO	J:164563
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:155856
Biological Process	GO:1904417	positive regulation of xenophagy	IGI	J:178691
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:75391
Biological Process	GO:0006468	protein phosphorylation	IDA	J:93432
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0030641	regulation of cellular pH	IMP	J:228528
Biological Process	GO:0051493	regulation of cytoskeleton organization	TAS	J:180564
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	IMP	J:135485
Biological Process	GO:2000641	regulation of early endosome to late endosome transport	TAS	J:180564
Biological Process	GO:0090170	regulation of Golgi inheritance	TAS	J:180564
Biological Process	GO:0030278	regulation of ossification	IGI	J:157951
Biological Process	GO:0032872	regulation of stress-activated MAPK cascade	TAS	J:180564
Biological Process	GO:0070849	response to epidermal growth factor	ISO	J:164563
Biological Process	GO:0043330	response to exogenous dsRNA	IDA	J:84896
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:84896
Biological Process	GO:0009636	response to toxic substance	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	IMP	J:69456
Biological Process	GO:0007165	signal transduction	TAS	J:72305
Biological Process	GO:0042770	signal transduction in response to DNA damage	ISO	J:164563
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0048538	thymus development	IGI	J:144862
Biological Process	GO:0030878	thyroid gland development	IGI	J:144862
Biological Process	GO:0060440	trachea formation	IGI	J:214083
Biological Process	GO:0098792	xenophagy	IGI	J:178691