GO Annotations Graph

• Symbol: Mmp13
• Name: matrix metallopeptidase 13
• ID: MGI:1340026

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:155856
Molecular Function	GO:0005518	collagen binding	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0001968	fibronectin binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:155856
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0004222	metalloendopeptidase activity	IDA	J:115561
Molecular Function	GO:0004222	metalloendopeptidase activity	IDA	J:87621
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:72247
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IDA	J:94273
Molecular Function	GO:0004252	serine-type endopeptidase activity	IEA	J:72245
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0031012	extracellular matrix	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2533953
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0046581	intercellular canaliculus	ISO	J:155856
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Biological Process	GO:0030282	bone mineralization	IMP	J:130351
Biological Process	GO:0060349	bone morphogenesis	ISO	J:164563
Biological Process	GO:0030574	collagen catabolic process	IMP	J:130351
Biological Process	GO:0030574	collagen catabolic process	ISO	J:164563
Biological Process	GO:0030574	collagen catabolic process	IBA	J:265628
Biological Process	GO:0030574	collagen catabolic process	IDA	J:94723
Biological Process	GO:0001958	endochondral ossification	IMP	J:130351
Biological Process	GO:0022617	extracellular matrix disassembly	IMP	J:130351
Biological Process	GO:0022617	extracellular matrix disassembly	ISO	J:164563
Biological Process	GO:0030198	extracellular matrix organization	IBA	J:265628
Biological Process	GO:0003417	growth plate cartilage development	IGI	J:171277
Biological Process	GO:0007507	heart development	ISO	J:155856
Biological Process	GO:1904244	positive regulation of pancreatic trypsinogen secretion	ISO	J:155856
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0019538	protein metabolic process	IDA	J:115561
Biological Process	GO:0006508	proteolysis	IMP	J:130351
Biological Process	GO:0009725	response to hormone	ISO	J:155856