GO Annotations Graph

• Symbol: Cth
• Name: cystathionine gamma lyase
• ID: MGI:1339968

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0004121	cystathionine beta-lyase activity	ISO	J:155856
Molecular Function	GO:0004123	cystathionine gamma-lyase activity	ISO	J:164563
Molecular Function	GO:0004123	cystathionine gamma-lyase activity	IBA	J:265628
Molecular Function	GO:0004123	cystathionine gamma-lyase activity	IDA	J:91125
Molecular Function	GO:0047982	homocysteine desulfhydrase activity	IEA	J:72245
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0080146	L-cysteine desulfhydrase activity	IEA	J:72245
Molecular Function	GO:0044540	L-cystine L-cysteine-lyase (deaminating)	ISO	J:164563
Molecular Function	GO:0044540	L-cystine L-cysteine-lyase (deaminating)	IDA	J:179897
Molecular Function	GO:0044540	L-cystine L-cysteine-lyase (deaminating)	IMP	J:182483
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:182483
Molecular Function	GO:0005515	protein binding	IPI	J:179897
Molecular Function	GO:0030170	pyridoxal phosphate binding	ISO	J:164563
Molecular Function	GO:0030170	pyridoxal phosphate binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2408528
Biological Process	GO:0008652	amino acid biosynthetic process	IEA	J:60000
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0019344	cysteine biosynthetic process	ISO	J:164563
Biological Process	GO:0019344	cysteine biosynthetic process	ISO	J:155856
Biological Process	GO:0019343	cysteine biosynthetic process via cystathionine	ISO	J:164563
Biological Process	GO:0019343	cysteine biosynthetic process via cystathionine	IBA	J:265628
Biological Process	GO:0006749	glutathione metabolic process	ISO	J:155856
Biological Process	GO:0050667	homocysteine metabolic process	ISO	J:155856
Biological Process	GO:0070814	hydrogen sulfide biosynthetic process	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:179897
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	IMP	J:179897
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:1904831	positive regulation of aortic smooth muscle cell differentiation	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:179897
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:179897
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0044524	protein sulfhydration	IDA	J:179897
Biological Process	GO:0044524	protein sulfhydration	ISO	J:164563
Biological Process	GO:0044524	protein sulfhydration	IMP	J:182483
Biological Process	GO:0018272	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	ISO	J:164563
Biological Process	GO:0019346	transsulfuration	ISO	J:164563
Biological Process	GO:0019346	transsulfuration	IBA	J:265628