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GO Annotations Graph
Symbol
Name
ID
Smad6
SMAD family member 6
MGI:1336883

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0003682chromatin bindingISOJ:164563
Molecular FunctionGO:0070410co-SMAD bindingISOJ:164563
Molecular FunctionGO:0003677DNA bindingIEAJ:60000
Molecular FunctionGO:0070411I-SMAD bindingISOJ:164563
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:109361
Molecular FunctionGO:0005515protein bindingIPIJ:201257
Molecular FunctionGO:0005515protein bindingIPIJ:109361
Molecular FunctionGO:0005515protein bindingIPIJ:200447
Molecular FunctionGO:0070412R-SMAD bindingISOJ:164563
Molecular FunctionGO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingISOJ:164563
Molecular FunctionGO:0003700transcription factor activity, sequence-specific DNA bindingIEAJ:72247
Molecular FunctionGO:0044212transcription regulatory region DNA bindingISOJ:164563
Molecular FunctionGO:0030617transforming growth factor beta receptor, inhibitory cytoplasmic mediator activityISOJ:164563
Molecular FunctionGO:0070698type I activin receptor bindingISOJ:164563
Molecular FunctionGO:0034713type I transforming growth factor beta receptor bindingISOJ:164563
Molecular FunctionGO:0031625ubiquitin protein ligase bindingISOJ:164563
Cellular ComponentGO:0005622intracellularIEAJ:72247
Cellular ComponentGO:0005634nucleusISOJ:164563
Cellular ComponentGO:0043234protein complexISOJ:198828
Cellular ComponentGO:0005667transcription factor complexIEAJ:72247
Biological ProcessGO:0035904aorta developmentIMPJ:222159
Biological ProcessGO:0030509BMP signaling pathwayISOJ:164563
Biological ProcessGO:0060948cardiac vascular smooth muscle cell developmentTASJ:169941
Biological ProcessGO:0031589cell-substrate adhesionISOJ:164563
Biological ProcessGO:0060976coronary vasculature developmentIMPJ:222159
Biological ProcessGO:0060977coronary vasculature morphogenesisTASJ:169941
Biological ProcessGO:0045444fat cell differentiationISOJ:164563
Biological ProcessGO:0003170heart valve developmentIMPJ:222159
Biological ProcessGO:0006955immune responseISOJ:164563
Biological ProcessGO:0035556intracellular signal transductionISOJ:164563
Biological ProcessGO:0043066negative regulation of apoptotic processISOJ:164563
Biological ProcessGO:0030514negative regulation of BMP signaling pathwayISOJ:164563
Biological ProcessGO:0008285negative regulation of cell proliferationISOJ:164563
Biological ProcessGO:0060394negative regulation of pathway-restricted SMAD protein phosphorylationISOJ:164563
Biological ProcessGO:0010991negative regulation of SMAD protein complex assemblyISOJ:164563
Biological ProcessGO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayISOJ:164563
Biological ProcessGO:0045908negative regulation of vasodilationTASJ:169941
Biological ProcessGO:0045907positive regulation of vasoconstrictionTASJ:169941
Biological ProcessGO:0006355regulation of transcription, DNA-templatedIEAJ:72247
Biological ProcessGO:0006355regulation of transcription, DNA-templatedIEAJ:60000
Biological ProcessGO:0006351transcription, DNA-templatedIEAJ:60000
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayIEAJ:72247
Biological ProcessGO:0003281ventricular septum developmentIMPJ:222159
Biological ProcessGO:0007352zygotic specification of dorsal/ventral axisISOJ:164563


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory