GO Annotations Graph

• Symbol: Lats1
• Name: large tumor suppressor
• ID: MGI:1333883

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:169049
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0000922	spindle pole	ISO	J:164563
Cellular Component	GO:0000922	spindle pole	IBA	J:265628
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0051220	cytoplasmic sequestering of protein	ISO	J:164563
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0035329	hippo signaling	ISO	J:164563
Biological Process	GO:0035329	hippo signaling	IBA	J:265628
Biological Process	GO:0035329	hippo signaling	IGI	J:134270
Biological Process	GO:0035329	hippo signaling	IGI	J:134270
Biological Process	GO:0035329	hippo signaling	IGI	J:134270
Biological Process	GO:0009755	hormone-mediated signaling pathway	IDA	J:52536
Biological Process	GO:0001827	inner cell mass cell fate commitment	IGI	J:199456
Biological Process	GO:0001828	inner cell mass cellular morphogenesis	IGI	J:199456
Biological Process	GO:0030216	keratinocyte differentiation	IGI	J:134270
Biological Process	GO:0030216	keratinocyte differentiation	IGI	J:134270
Biological Process	GO:0030216	keratinocyte differentiation	IGI	J:134270
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	ISO	J:164563
Biological Process	GO:0000278	mitotic cell cycle	IEA	J:72247
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	IMP	J:169049
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0008104	protein localization	IGI	J:147050
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0030833	regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0033146	regulation of intracellular estrogen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0046620	regulation of organ growth	IBA	J:265628
Biological Process	GO:0043254	regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	IMP	J:169049
Biological Process	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0000819	sister chromatid segregation	ISO	J:164563