GO Annotations Graph

• Symbol: Ppp2ca
• Name: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
• ID: MGI:1321159

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0050811	GABA receptor binding	IDA	J:116460
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:145554
Molecular Function	GO:0019209	kinase activator activity	ISO	J:332288
Molecular Function	GO:0019210	kinase inhibitor activity	IMP	J:292012
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0017018	myosin phosphatase activity	IEA	J:72245
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	IEA	J:60000
Molecular Function	GO:1990405	protein antigen binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:213891
Molecular Function	GO:0005515	protein binding	IPI	J:154173
Molecular Function	GO:0005515	protein binding	IPI	J:201565
Molecular Function	GO:0005515	protein binding	IPI	J:213903
Molecular Function	GO:0005515	protein binding	IPI	J:266118
Molecular Function	GO:0005515	protein binding	IPI	J:116445
Molecular Function	GO:0005515	protein binding	IPI	J:84681
Molecular Function	GO:0005515	protein binding	IPI	J:104056
Molecular Function	GO:0005515	protein binding	IPI	J:145554
Molecular Function	GO:0005515	protein binding	IPI	J:145554
Molecular Function	GO:0005515	protein binding	IPI	J:53684
Molecular Function	GO:0005515	protein binding	IPI	J:116460
Molecular Function	GO:0005515	protein binding	IPI	J:145554
Molecular Function	GO:0005515	protein binding	IPI	J:145554
Molecular Function	GO:0005515	protein binding	IPI	J:84681
Molecular Function	GO:0005515	protein binding	IPI	J:145554
Molecular Function	GO:0005515	protein binding	IPI	J:145554
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0043422	protein kinase B binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	IMP	J:331917
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	IMP	J:259480
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	ISO	J:155856
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	IBA	J:265628
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	IMP	J:292012
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	ISO	J:332288
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	TAS	J:50519
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0048156	tau protein binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000775	chromosome, centromeric region	IDA	J:130184
Cellular Component	GO:0005737	cytoplasm	IDA	J:62090
Cellular Component	GO:0005737	cytoplasm	IDA	J:51933
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:201873
Cellular Component	GO:0005829	cytosol	IDA	J:84681
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:62090
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0000159	protein phosphatase type 2A complex	ISO	J:164563
Cellular Component	GO:0000159	protein phosphatase type 2A complex	ISO	J:145554
Cellular Component	GO:0000159	protein phosphatase type 2A complex	IDA	J:116445
Cellular Component	GO:0045202	synapse	IDA	J:105399
Cellular Component	GO:0045202	synapse	IEP	J:105399
Cellular Component	GO:0045202	synapse	IDA	J:105399
Cellular Component	GO:0045202	synapse	IEP	J:105399
Cellular Component	GO:0045202	synapse	IDA	J:105399
Cellular Component	GO:0045202	synapse	IDA	J:105399
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0051321	meiotic cell cycle	IEA	J:60000
Biological Process	GO:0007498	mesoderm development	IMP	J:50519
Biological Process	GO:0000278	mitotic cell cycle	IBA	J:265628
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:1904539	negative regulation of glycolytic process through fructose-6-phosphate	IMP	J:292012
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:259480
Biological Process	GO:0035970	peptidyl-threonine dephosphorylation	ISO	J:164563
Biological Process	GO:1904540	positive regulation of glycolytic process through fructose-6-phosphate	ISO	J:332288
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IMP	J:331917
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	TAS	J:51933
Biological Process	GO:0051726	regulation of cell cycle	TAS	J:50519
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0031952	regulation of protein autophosphorylation	ISO	J:145554
Biological Process	GO:0042176	regulation of protein catabolic process	ISO	J:145554
Biological Process	GO:0001932	regulation of protein phosphorylation	ISO	J:145554
Biological Process	GO:0010469	regulation of signaling receptor activity	ISO	J:145554
Biological Process	GO:0043029	T cell homeostasis	IMP	J:259480