GO Annotations Graph

• Symbol: Slit2
• Name: slit guidance ligand 2
• ID: MGI:1315205

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0045499	chemorepellent activity	IMP	J:90079
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265607
Molecular Function	GO:0005095	GTPase inhibitor activity	ISO	J:164563
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	ISO	J:155856
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0043237	laminin-1 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:194150
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0043394	proteoglycan binding	ISO	J:164563
Molecular Function	GO:0048495	Roundabout binding	ISO	J:164563
Molecular Function	GO:0048495	Roundabout binding	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	TAS	J:86040
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:86040
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9010544
Biological Process	GO:0003180	aortic valve morphogenesis	IMP	J:244269
Biological Process	GO:0048846	axon extension involved in axon guidance	ISO	J:164563
Biological Process	GO:0007411	axon guidance	ISO	J:164563
Biological Process	GO:0007411	axon guidance	IGI	J:89780
Biological Process	GO:0007411	axon guidance	IGI	J:86465
Biological Process	GO:0007411	axon guidance	IDA	J:87191
Biological Process	GO:0007411	axon guidance	IMP	J:107695
Biological Process	GO:0007411	axon guidance	IGI	J:107695
Biological Process	GO:0007411	axon guidance	IGI	J:89780
Biological Process	GO:0007411	axon guidance	IDA	J:86040
Biological Process	GO:0007409	axonogenesis	IMP	J:109226
Biological Process	GO:0007409	axonogenesis	IDA	J:109226
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:106011
Biological Process	GO:0098609	cell-cell adhesion	IMP	J:106011
Biological Process	GO:0071504	cellular response to heparin	ISO	J:164563
Biological Process	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration	ISO	J:164563
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0021972	corticospinal neuron axon guidance through spinal cord	ISO	J:164563
Biological Process	GO:0033563	dorsal/ventral axon guidance	IMP	J:107695
Biological Process	GO:0033563	dorsal/ventral axon guidance	IGI	J:107695
Biological Process	GO:0001701	in utero embryonic development	IMP	J:141875
Biological Process	GO:0050929	induction of negative chemotaxis	ISO	J:164563
Biological Process	GO:0001822	kidney development	IMP	J:231949
Biological Process	GO:0060763	mammary duct terminal end bud growth	IMP	J:106011
Biological Process	GO:0060603	mammary gland duct morphogenesis	IMP	J:106011
Biological Process	GO:0060603	mammary gland duct morphogenesis	IGI	J:106011
Biological Process	GO:0001656	metanephros development	IMP	J:90324
Biological Process	GO:0008045	motor neuron axon guidance	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050919	negative chemotaxis	ISO	J:164563
Biological Process	GO:0050919	negative chemotaxis	IBA	J:265628
Biological Process	GO:0050919	negative chemotaxis	IMP	J:90079
Biological Process	GO:0050919	negative chemotaxis	IMP	J:109226
Biological Process	GO:0030837	negative regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0030517	negative regulation of axon extension	IDA	J:87191
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	IBA	J:265628
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:141875
Biological Process	GO:0090288	negative regulation of cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0070100	negative regulation of chemokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010596	negative regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IGI	J:141875
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0010593	negative regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0002689	negative regulation of leukocyte chemotaxis	ISO	J:164563
Biological Process	GO:0090027	negative regulation of monocyte chemotaxis	ISO	J:155856
Biological Process	GO:0071676	negative regulation of mononuclear cell migration	ISO	J:164563
Biological Process	GO:0090024	negative regulation of neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0090260	negative regulation of retinal ganglion cell axon guidance	ISO	J:164563
Biological Process	GO:0051058	negative regulation of small GTPase mediated signal transduction	ISO	J:164563
Biological Process	GO:0071672	negative regulation of smooth muscle cell chemotaxis	ISO	J:164563
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	ISO	J:164563
Biological Process	GO:0043116	negative regulation of vascular permeability	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0048812	neuron projection morphogenesis	IGI	J:107695
Biological Process	GO:0048812	neuron projection morphogenesis	IMP	J:107695
Biological Process	GO:0021772	olfactory bulb development	IGI	J:109226
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0003184	pulmonary valve morphogenesis	IMP	J:244269
Biological Process	GO:0031290	retinal ganglion cell axon guidance	ISO	J:164563
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IBA	J:265628
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IGI	J:111137
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IGI	J:73904
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IGI	J:73904
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IMP	J:119315
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IGI	J:119315
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IMP	J:111137
Biological Process	GO:0035385	Roundabout signaling pathway	ISO	J:164563
Biological Process	GO:0022029	telencephalon cell migration	IGI	J:90079
Biological Process	GO:0001657	ureteric bud development	ISO	J:164563
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:244269