GO Annotations Graph

• Symbol: Hipk1
• Name: homeodomain interacting protein kinase 1
• ID: MGI:1314873

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:81640
Molecular Function	GO:0005515	protein binding	IPI	J:65176
Molecular Function	GO:0005515	protein binding	IPI	J:181102
Molecular Function	GO:0004672	protein kinase activity	ISS	J:50387
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004713	protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0003714	transcription corepressor activity	ISS	J:50387
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:162323
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:81640
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	IDA	J:81640
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISS	J:50387
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0016605	PML body	IBA	J:265628
Cellular Component	GO:0016605	PML body	IDA	J:81640
Biological Process	GO:0034333	adherens junction assembly	IMP	J:197686
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:106931
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:106931
Biological Process	GO:0008283	cell population proliferation	IGI	J:106931
Biological Process	GO:0008283	cell population proliferation	IGI	J:106931
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IMP	J:162323
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	IMP	J:162323
Biological Process	GO:0072577	endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA	J:265628
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI	J:106931
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI	J:106931
Biological Process	GO:0061072	iris morphogenesis	IMP	J:162323
Biological Process	GO:0060235	lens induction in camera-type eye	IMP	J:162323
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISS	J:50387
Biological Process	GO:0030182	neuron differentiation	IMP	J:162323
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:106931
Biological Process	GO:0043388	positive regulation of DNA binding	ISS	J:50387
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISS	J:50387
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010842	retina layer formation	IMP	J:162323
Biological Process	GO:0007224	smoothened signaling pathway	IBA	J:265628
Biological Process	GO:0007224	smoothened signaling pathway	IGI	J:106931